| Effects of 2-hydroxyoestradiol-17 beta on plasma luteinizing hormone, follicle-stimulating hormone and prolactin, and nuclear translocation of pituitary oestrogen receptors in ovariectomized ewes. | |
| | |
MedLine Citation:
|
PMID: 6290586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ability of oestradiol-17 beta (OE2) and 2-hydroxyoestradiol (2OH-OE2) to translocate pituitary oestrogen receptors to the nuclear compartment and to affect plasma concentrations of LH, FSH and prolactin was studied in ovariectomized ewes. Mean (+/- S.E.M.) nuclear oestrogen receptor levels (% of total pituitary oestrogen receptors) after intracarotid injections of 1.25 micrograms OE2, 400 micrograms 2OH-OE2 or vehicle were 8.7 +/- 2.3, 16.9 +/- 3.2 and 0.8 +/- 0.1% respectively. Whereas 1.25 or 12.5 micrograms OE2 significantly lowered plasma LH and FSH, 400 micrograms 2OH-OE2 did not affect plasma LH or FSH levels. Injection of 4000 micrograms 2OH-OE2 however, significantly affected plasma LH and FSH. Plasma prolactin levels were not significantly affected by the treatments. These data indicate a discrepancy between oestrogen receptor occupancy and effects on gonadotrophin and prolactin secretion after injection of catechol oestrogen. |
| | |
Authors:
|
I J Clarke; K Wynne; J W Funder; J K Findlay |
Related Documents
:
|
293406 - Identification in human seminal fluid of an inhibin-like factor which selectively regul... 9241636 - Superovulation of new zealand white rabbits by continuous infusion of follicle-stimulat... 1106206 - Pituitary responses to lrh in the postpartum periods. 10475636 - Effect of timing and size of photoperiod change on plasma fsh concentration and the cor... 196716 - Suppression of radioiodide accumulation by the thyroids and oocytes of japanese quail w... 21270096 - Acid retention accompanies reduced gfr in humans and increases plasma levels of endothe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of endocrinology Volume: 95 ISSN: 0022-0795 ISO Abbreviation: J. Endocrinol. Publication Date: 1982 Oct |
Date Detail:
|
Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 19-27 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Castration Estradiol / analogs & derivatives*, pharmacology Estrogens, Catechol / pharmacology* Female Follicle Stimulating Hormone / blood Gonadotropins, Pituitary / blood* Luteinizing Hormone / blood Pituitary Gland / drug effects* Prolactin / blood Receptors, Estrogen / drug effects* Sheep |
| Chemical | |
Reg. No./Substance:
|
0/Estrogens, Catechol; 0/Gonadotropins, Pituitary; 0/Receptors, Estrogen; 362-05-0/2-hydroxyestradiol; 50-28-2/Estradiol; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the effects of prostaglandin E2, prostacyclin and 1-24 adrenocorticotrophin on plasma ...
Next Document: A rapid direct radioimmunoassay for the measurement of oestrone sulphate in the milk of dairy cows a...