| Effects of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline (XW630) on osteoporosis in ovariectomized rats. | |
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MedLine Citation:
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PMID: 11324415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the effects of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline (XW630) on experimental osteoporosis in ovariectomized (OVX) rats. METHODS: Serum estradiol (E2) content and bone 1-carboxyglutamic acid-containing protein (BGP) content were measured by radioimmunoassay. With undecalcified bone section and tetracycline intraperitoneal labeling, the bone static and dynamic data were studied in right femur samples. RESULTS: After treatment with XW630 2.5 mg.kg-1, serum BGP content increased by 75.7% but there was no change in serum E2 content and uterus weight compared with OVX rats. Compared with OVX rats, the static data of trabecular bone volume/total tissue volume, trabecular bone volume/sponge bone volume, and mean trabecular plate density were enhanced after treatment with XW630 for 13 wk. The dynamic data of single-labeled surface, double-labeled surface, trabecular osteoid surface, and bone formation rate in tissue level in XW630 group were increased and osteoid maturation period was shortened. CONCLUSION: XW630 enhanced bone activation frequency and increased trabecular connectivity, stability, and strength. XW630 stimulated bone formation and inhibited bone resorption with no effect on reproductive system. |
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Authors:
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L Sun; M C Qiu; L L Weng; H Zheng; J S Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta pharmacologica Sinica Volume: 21 ISSN: 1671-4083 ISO Abbreviation: Acta Pharmacol. Sin. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2001-04-27 Completed Date: 2001-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100956087 Medline TA: Acta Pharmacol Sin Country: China |
Other Details:
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Languages: eng Pagination: 200-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Estradiol / blood Estrogens, Conjugated (USP) / pharmacology* Estrone / pharmacology Female Femur / drug effects* Humans Osteoporosis, Postmenopausal / metabolism* Ovariectomy Piperazines / pharmacology* Rats Rats, Wistar Tetracycline / pharmacology* Tetracyclines Uterus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/2-(3-estrone-N-ethyl-piperazine-methyl)tetracycline; 0/Estrogens, Conjugated (USP); 0/Piperazines; 0/Tetracyclines; 50-28-2/Estradiol; 53-16-7/Estrone; 60-54-8/Tetracycline |
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