Document Detail

Effects of 17 beta-estradiol on coronary microvascular responses to endothelin-1.
MedLine Citation:
PMID:  8853349     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to examine the effects of 17 beta-estradiol on responses of coronary microvessels to endothelin-1 (ET-1). With the use of isolated pressurized coronary microvessels from the left ventricle of male or female dogs, constrictions to ET-1 were similar in vessels from male and female dogs. 17 beta-Estradiol (1 microM) attenuated constriction to ET-1 of small arteries from both male (percent constriction at 10 microM control: 39 +/- 9%, estradiol: 3 +/- 2%; P < 0.05) and female (percent constriction at 10 microM control: 39 +/- 8%, estradiol: 6 +/- 3%; P < 0.05) dogs similarly. In contrast, testosterone (1 microM) had no effect on constriction to ET-1. Constrictions to ET-1 were completely abolished by BQ-123 (1 microM), a selective ETA-receptor antagonist, and enhanced by BQ-788 (1 microM), a selective ETB-receptor antagonist. Constrictions to ET-1 alone were not altered by indomethacin (Indo, 10 microM) or NG-nitro-L-arginine (L-NNA, 100 microM). 17 beta-Estradiol produced dose-dependent relaxation of coronary microvessels preconstricted with ET-1 that was similar to the response to testosterone and progesterone. Indo or L-NNA alone had no effect on relaxation to 17 beta-estradiol. However, the combination of Indo and L-NNA attenuated Taxation to 17 beta-estradiol (percent dilation at 1 microM control: 64 +/- 13%; Indo plus L-NNA: 21 +/- 6%; P < 0.05) but did not affect relaxation to testosterone. Thus 17 beta-estradiol attenuated constrictions of coronary microvessels to ET-1 more than did similar concentrations of testosterone. The ability of 17 beta-estradiol to modulate responses to endothelin may involve release of vasodilator prostaglandins and/or nitric oxide by 17 beta-estradiol.
K G Lamping; D W Nuno
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1117-24     Citation Subset:  IM    
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City 52242, USA.
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MeSH Terms
Blood Vessels / metabolism
Coronary Circulation / drug effects*
Endothelin-1 / pharmacology*
Epoprostenol / physiology
Estradiol / pharmacology*
Gonadal Steroid Hormones / pharmacology
Microcirculation / drug effects
Nitric Oxide / physiology
Receptors, Endothelin / metabolism
Saponins / pharmacology
Vasoconstriction / drug effects,  physiology
Vasodilation / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Endothelin-1; 0/Gonadal Steroid Hormones; 0/Receptors, Endothelin; 0/Saponins; 10102-43-9/Nitric Oxide; 35121-78-9/Epoprostenol; 50-28-2/Estradiol

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