| Effects of the 14F hemopump on coronary hemodynamics in patients undergoing high-risk coronary angioplasty. | |
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MedLine Citation:
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PMID: 9588415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The influence of the 14F Hemopump on coronary hemodynamics in patients with coronary artery disease remains unknown. METHODS: Systemic and coronary hemodynamic measurements were obtained in eight patients among 13 who underwent high-risk coronary angioplasty in our institution with the support of the Hemopump. Coronary blood flow velocity was measured with a 0.014-inch Doppler-tipped guide wire both proximal and distal to the target lesion. RESULTS: Angioplasty decreases the diameter coronary stenosis from 76% +/- 21% to 22% +/- 11%. Hemopump support did not change systemic hemodynamics either before or after angioplasty. During angioplasty Hemopump support decreased the pulmonary capillary wedge pressure from 23.5 +/- 8.5 mm Hg to 18.6 +/- 7 mm Hg (p = 0.013). No changes in either heart rate, mean and systolic aortic pressures, and cardiac index were observed throughout the procedure. After successful angioplasty was performed, the ratio of proximal to distal flow velocity decreased from 2.11 +/- 1 to 1.65 +/- 0.2 (p = 0.05). However, Hemopump did not affect absolute coronary blood flow velocities or the phasic pattern of flow velocities (diastolic systolic velocity ratio, diastolic and systolic velocity integrals) either in proximal or distal locations either before or after angioplasty. CONCLUSIONS: This study shows that although the 14F Hemopump produces unloading of the left ventricle, it does not importantly alter coronary hemodynamics when systemic hemodynamics are stable. Whether the Hemopump would maintain or improve coronary blood flow in compromised patients remains to be determined. |
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Authors:
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J L Dubois-Randé; E Teiger; J Garot; E Aptecar; J M Pernès; D Tixier; P Gueret; D Loisance; P Dupouy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 135 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-05-19 Completed Date: 1998-05-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 844-9 Citation Subset: AIM; IM |
Affiliation:
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Service des Explorations Fonctionnelles, Fédération de Cardiologie et Centre de Recherche Chirurgical (CNRS), Hôpital Henri Mondor, Créteil, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / instrumentation* Blood Flow Velocity / physiology Coronary Circulation / physiology Coronary Disease / physiopathology, therapy* Diastole / physiology Heart-Assist Devices* Hemodynamics / physiology* Humans Male Middle Aged Monitoring, Physiologic Pulmonary Wedge Pressure / physiology Risk Factors Systole / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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