| Effects of (14)C-labelled precursor feeding on production of beauvericin, enniatins H, I, and MK1688 by Fusarium oxysporum KFCC11363P. | |
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MedLine Citation:
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PMID: 22019403 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The effects of (14)C-labelled precursor feeding on the production of cyclic hexadepsipeptides were investigated by the mycelium of F. oxysporum KFCC11363P producing beauvericin along with enniatins H, I, and MK1688. Most (14)C-phenylalanine and (14)C-valine were incorporated easily into the biosynthetic pathway of (14)C-labelled beauvericin in vivo by the mycelium. However, only a small amount of (14)C-labelled enniatins could be detected by feeding of (14)C-valine. When l-valine was fed as a precursor to the mycelium at large scale, the level of beauvericin increased to maximum followed by enniatins H and I. Feeding of l-valine did not affect the production of enniatin MK1688. These results suggest that l-valine feeding led to the production of d-hydroxyisovaleic acid in the mycelium and specifically enhanced the production of cyclic hexadepsipeptides containing d-hydroxyisovaleic acid, such as beauvericin and enniatins H and I. |
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Authors:
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Hee-Seok Lee; Kyung-Ai Kim; Dong-Geun Seo; Chan Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-21 |
Journal Detail:
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Title: Journal of bioscience and bioengineering Volume: - ISSN: 1347-4421 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888800 Medline TA: J Biosci Bioeng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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