Document Detail

Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.
MedLine Citation:
PMID:  8917375     Owner:  NLM     Status:  MEDLINE    
In this study we examined whether chemopreventive agents that had each been shown to be effective against lung tuorigenesis induced in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were more effective when applied together as a "cocktail" than as individual compounds. Groups of A/J mice were fed a diet containing 1,4-phenylenebis(methylene)selenocyanate (p-XSC; 5 ppm as selenium, 0.0005%), phenethyl isothiocyanate (PEITC; 0.008%), indole-3-carbinol (I3C; 0.18%), d-limonene (d-L, 0.63%), or a mixture of all four at the above levels. Mice were fed experimental diets (AIN-76A plus a chemopreventive agent, or a mixture of the four chemopreventive agents) for 17 weeks. One week after beginning the experimental diets, the animals received a single i.p. injection of 10 mumol NNK (2.07 mg) in 0.1 ml saline. Sixteen weeks after the NNK application the bioassay was terminated. Dietary p-XSC, PEITC, I3C, d-L, and their admixture reduced significantly the number of lung tumors per mouse from 8.1 in the positive control to 3.2, 3.7, 4.9, 2.4, and 2.5, respectively (p < 0.05). The inhibition of lung tumor multiplicity in mice fed either the mixture or d-L alone was also significantly stronger than in those fed the diet containing only I3C. However, neither individual agents nor their mixture had a measurable effect on lung tumor incidence. Although the effect of the mixture on lung tumor incidence in this assay remained imperfect, this preliminary investigation provides some basis for the future design of chemoprevention studies.
K el-Bayoumy; P Upadhyaya; D H Desai; S Amin; D Hoffmann; E L Wynder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anticancer research     Volume:  16     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1996 Sep-Oct
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2709-12     Citation Subset:  IM    
American Health Foundation, Valhalla, NY 10595, USA.
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MeSH Terms
Anticarcinogenic Agents / administration & dosage,  pharmacology*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  pharmacology*
Carcinogens / toxicity*
Drug Screening Assays, Antitumor
Indoles / administration & dosage,  pharmacology
Isothiocyanates / administration & dosage,  pharmacology
Lung Neoplasms / chemically induced,  prevention & control*
Neoplasms, Experimental / chemically induced,  prevention & control
Nitrosamines / toxicity*
Organoselenium Compounds / administration & dosage,  pharmacology
Terpenes / administration & dosage,  pharmacology
Grant Support
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Cyclohexenes; 0/Indoles; 0/Isothiocyanates; 0/Nitrosamines; 0/Organoselenium Compounds; 0/Terpenes; 138-86-3/limonene; 2257-09-2/phenethyl isothiocyanate; 64091-91-4/4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; 700-06-1/indole-3-carbinol; 85539-83-9/1,4-phenylenebis(methylene)selenocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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