Document Detail


Effects of 13, 14-dehydroprostacyclin methyl ester on the feline intestinal vascular bed.
MedLine Citation:
PMID:  341229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of a stable PGI2 analog, 13, 14-dehydro-PGI2 methyl ester and several vasoactive hormones were compared in the feline intestinal vascular bed under conditions of controlled blood flow so that changes in perfusion pressure directly reflect changes in vascular resistance. The PGI2 analog decreased perfusion pressure in a dose-dependent fashion when injected in the range of dose of 0.03-3 microgram and was quite similar to PGE2 whereas isoproterenol was somewhat more potent as a vasodilagor in the feline intestinal vascular bed. The present data show that 13, 14-dehydro-PGI2 methyl ester has potent vasodilator activity in the intestinal vascular bed.
Authors:
P W Paustian; B M Chapnick; L P Feigen; A L Hyman; P J Kadowitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  14     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1977  
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2009-06-30    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1141-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Cats
Dose-Response Relationship, Drug
Epoprostenol / administration & dosage,  pharmacology*
Female
Intestines / blood supply*
Isoproterenol / pharmacology
Male
Prostaglandins / pharmacology*
Prostaglandins E / administration & dosage,  pharmacology
Vascular Resistance / drug effects*
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins E; 35121-78-9/Epoprostenol; 51-84-3/Acetylcholine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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