| Effects of 1,25-dihydroxyvitamin D3 on calcium and phosphorus homeostasis in sheep fed diets either adequate or restricted in calcium content. | |
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MedLine Citation:
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PMID: 19962267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It was the aim of the present study to collect basic data on calcium (Ca) and phosphorus (P) homoeostasis in sheep. Two series of experiments were carried out to investigate the effects of 1,25-dihydroxyvitammin D(3) (calcitriol) in supraphysiological dosage in combination with varying alimentary Ca supply. In the first series, blood samples were collected over 72 h to determine the concentrations of total Ca (Ca), ionized Ca (Ca(2+)), inorganic phosphate (P(i)), and the bone resorption marker CrossLaps (CL). In the second series, measurements were carried out over 12h. In addition, urine samples were collected to calculate the fractional excretions (FE) of Ca and P(i). Changes in plasma macromineral concentrations (P<0.01) as well as in CL (P<0.001) and endogenous calcitriol (P<0.05) were observed in the alimentary Ca-restricted animals, indicating that the reduction of daily Ca intake challenged the animals' macromineral homeostatic mechanisms. However, the Ca-restricted diet had an effect on neither FE of Ca nor on FE of P(i). The treatment resulted in peak serum calcitriol concentrations between 1,900 and 2,500 pg/mL, and supraphysiological concentrations were maintained for the next 48 h. Irrespective of dietary Ca, calcitriol had hypercalcemic and hyperphosphatemic effects. An increase in CL was revealed only in the Ca-restricted, calcitriol-treated sheep (P<0.01), reflecting a remarkable enhancement of Ca mobilization from the bone by calcitriol exclusively in this group. From these data, it can be concluded that the sheep can be a suitable animal model for studying catabolic effects of Ca deficiency and calcitriol on bone metabolism. |
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Authors:
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M R Wilkens; N Mrochen; G Breves; B Schröder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-25 |
Journal Detail:
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Title: Domestic animal endocrinology Volume: 38 ISSN: 1879-0054 ISO Abbreviation: Domest. Anim. Endocrinol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 190-9 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physiology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany. Mirja.Wilkens@tiho-hannover.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed* Animals Biological Markers / metabolism Bone Resorption / metabolism Bone and Bones / metabolism Calcitriol / administration & dosage*, metabolism Calcium / metabolism* Calcium, Dietary / administration & dosage Collagen / metabolism* Female Hypercalcemia / chemically induced Hyperphosphatemia / chemically induced Peptide Fragments / metabolism* Phosphates / metabolism Phosphorus / metabolism* Sheep, Domestic |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Calcium, Dietary; 0/Peptide Fragments; 0/Phosphates; 0/glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; 32222-06-3/Calcitriol; 7440-70-2/Calcium; 7723-14-0/Phosphorus; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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