Document Detail


Effects of [(123)I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats.
MedLine Citation:
PMID:  22960183     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [(123)I]ADAM ([(123)I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [(123)I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [(123)I]ADAM was not toxic in an animal pregnancy model.
Authors:
K W Chang; M C Lin; S Y Lee; H Y Chen; C C Chen; Y K Fu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  70     ISSN:  1872-9800     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  -    
Other Details:
Languages:  ENG     Pagination:  2646-2651     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Institute of Nuclear Energy Research, Division of Isotope Application, Taoyuan County, Taiwan.
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