Document Detail

Effects of 10-ppm hydrogen sulfide inhalation in exercising men and women. Cardiovascular, metabolic, and biochemical responses.
MedLine Citation:
PMID:  9048318     Owner:  NLM     Status:  MEDLINE    
This study examined the acute effects of 10-ppm hydrogen sulfide (H2S) inhalation, a concentration equal to its occupational exposure limit, on the cardiovascular, metabolic, and biochemical responses in healthy volunteers. Fifteen men and 13 women completed two 30-minute exercise sessions at 50% of their maximal oxygen uptake, during which they inhaled medical air or 10 ppm H2S in a blind manner. Arterial and finger-prick blood samples were obtained before and during the final minute of exercise. Muscle biopsies were withdrawn from the right vastus lateralis immediately after exercise. Cardiorespiratory measurements were monitored using an automated metabolic cart interfaced with an electrocardiogram and blood pressure apparatus. A significant decrease in oxygen uptake (VO2), with a concomitant increase in blood lactate, was observed in men and women as a result of H2S exposure. No significant changes were observed in arterial blood parameters and the cardiovascular responses under these conditions. Muscle lactate, as well as the activities of lactate dehydrogenase, citrate synthase, and cytochrome oxidase, were not significantly altered by H2S exposure. However, there was a tendency for muscle lactate to increase and citrate synthase activity to decrease in both genders in the presence of H2S. It appeared that 10-ppm H2S inhalation reduced VO2 during exercise, most likely by inhibiting the aerobic capacity of the exercising muscle. These findings question the scientific validity of the current occupational exposure limit for H2S.
Y Bhambhani; R Burnham; G Snydmiller; I MacLean
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  39     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-12     Completed Date:  1997-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-9     Citation Subset:  IM; S    
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Administration, Inhalation
Analysis of Variance
Blood Gas Analysis
Cardiovascular System / drug effects*
Citrate (si)-Synthase / metabolism
Electron Transport Complex IV / metabolism
Energy Metabolism / drug effects
Exercise / physiology*
Hydrogen Sulfide / administration & dosage,  pharmacology*
L-Lactate Dehydrogenase / metabolism
Lactic Acid / metabolism
Linear Models
Maximum Allowable Concentration
Muscle, Skeletal / drug effects,  metabolism
Occupational Exposure
Sex Factors
Reg. No./Substance:
50-21-5/Lactic Acid; 7783-06-4/Hydrogen Sulfide; EC Dehydrogenase; EC Transport Complex IV; EC (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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