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Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.
MedLine Citation:
PMID:  23411798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.
Authors:
Lynda M Stuart; Nicholas Paquette; Laurent Boyer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  -     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Developmental Immunology/CCIB, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA. [2] The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
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