Document Detail

Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.
MedLine Citation:
PMID:  23411798     Owner:  NLM     Status:  MEDLINE    
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.
Lynda M Stuart; Nicholas Paquette; Laurent Boyer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-15
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-04-18     Revised Date:  2014-06-20    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
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MeSH Terms
Arabidopsis / immunology,  microbiology
Arabidopsis Proteins / physiology
Bacteria / chemistry,  immunology,  pathogenicity
Bacterial Infections / immunology
Bacterial Proteins / physiology
Flagella / immunology
Host-Pathogen Interactions / immunology*
Immunity, Innate / immunology*
Immunologic Surveillance / immunology
Metagenome / immunology
Models, Immunological*
Protein Biosynthesis
Protein Kinases / physiology
Receptors, Pattern Recognition / immunology*
Signal Transduction / physiology
Toll-Like Receptors / immunology
Virulence / immunology
Grant Support
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Bacterial Proteins; 0/Receptors, Pattern Recognition; 0/Toll-Like Receptors; EC 2.7.-/Protein Kinases; EC 2.7.1.-/FLS2 protein, Arabidopsis

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