Document Detail

Effector pathways during eczematous dermatitis: where inflammation meets cell death.
MedLine Citation:
PMID:  19601979     Owner:  NLM     Status:  MEDLINE    
During eczematous skin inflammation, the main constituents of the skin, keratinocytes (KC), play an important role in inducing and shaping the immunological response to environmental stimuli. This review focuses on the epidermal inflammation caused by keratinocyte-T cell interactions arising from a disturbed barrier function of the skin. In eczematous dermatitis, activated dermis- and epidermis-infiltrating T cells target KC for apoptosis. In turn, damaged KC respond by secreting inflammatory mediators, thus effecting further recruitment of immunocytes to inflamed skin. Further advances will come from identification of the immunoregulatory mechanisms involved in the pathogenesis of eczematous dermatitis. Potential therapeutic interventions are discussed.
Andreas Kerstan; Martin Leverkus; Axel Trautmann
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-07
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-17     Completed Date:  2009-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  893-9     Citation Subset:  IM    
Department of Dermatology, Venerology and Allergology, University of W??rzburg, Germany.
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MeSH Terms
Apoptosis / immunology*
Dermatitis, Allergic Contact / etiology,  immunology*,  metabolism,  pathology*
Inflammation / immunology*
Keratinocytes / immunology
T-Lymphocytes / immunology

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