| Effector caspases and leukemia. | |
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MedLine Citation:
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PMID: 21647292 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes. Fourteen mammalian caspases have been identified and can be divided into two groups: inflammatory caspases and apoptotic caspases. Based on the structure and function, the apoptotic caspases are further grouped into initiator/apical caspases (caspase-2, -8, -9, and -10) and effector/executioner caspases (caspase-3, -6, and -7). In this paper, we discuss what we have learned about the role of individual effector caspase in mediating both apoptotic and nonapoptotic events, with special emphasis on leukemia-specific oncoproteins in relation to effector caspases. |
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Authors:
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Ying Lu; Guo-Qiang Chen |
Publication Detail:
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Type: Journal Article Date: 2011-04-14 |
Journal Detail:
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Title: International journal of cell biology Volume: 2011 ISSN: 1687-8884 ISO Abbreviation: Int J Cell Biol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101517861 Medline TA: Int J Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 738301 Citation Subset: - |
Affiliation:
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Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. |
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