| Effector and regulatory lymphocytes in asthmatic pregnant women. | |
| | |
MedLine Citation:
|
PMID: 20528830 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PROBLEM: Asthma influences pregnancy outcome and pregnancy affects asthma severity, but the immunologic mechanisms of these interactions are not fully elucidated. METHOD: The prevalence of lymphocyte subsets was identified by cell surface markers and intracellular FoxP3 staining, in healthy non-pregnant (HNP; N = 15), healthy pregnant (HP; N=33), asthmatic non-pregnant (ANP; N=62) and asthmatic pregnant (AP; N=61) women. RESULTS: Regulatory T cell (Treg) prevalence was higher in HP than in HNP subjects and showed a positive correlation with fetal birth weight, which was blunted in AP group. Treg prevalence was lower and invariable natural killer T cell prevalence was higher in AP patients (compared to HP). Higher naive and lower effector T cell prevalence was observed in AP than in ANP group. CONCLUSION: Pregnancy-induced increase in Treg cell prevalence is absent in asthmatic pregnancy that may interfere with physiological intrauterine growth. However, pregnancy-specific inhibition of asthmatic inflammation can be detected in uncomplicated asthmatic pregnancy. |
| | |
Authors:
|
Anikó Bohács; Aron Cseh; Balázs Stenczer; Veronika Müller; Gabriella Gálffy; Attila Molvarec; János Rigó; György Losonczy; Barna Vásárhelyi; Lilla Tamási |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 64 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 393-401 Citation Subset: IM |
Copyright Information:
|
© 2010 John Wiley & Sons A/S. |
Affiliation:
|
Department of Pulmonology, Semmelweis University, Budapest, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet.
Next Document: Expression of toll-like receptors in genital tract tissues from normal and HIV-infected men.