| Effectiveness of vardenafil versus papaverine in penile Doppler ultrasonography. | |
| | |
MedLine Citation:
|
PMID: 16037713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate erectile dysfunction, penile color Doppler ultrasound is currently considered the best method. But intracavernous injection is invasive and has adverse effects, such as prolonged erection and risk of priapism. In our study we want to evaluate whether vardenafil can be used instead of papaverine in penile Doppler ultrasonography. MATERIALS AND METHODS: A total of 24 patients with erectile dysfunction underwent color Doppler ultrasound before and after intracavernous injection of 60 mg papaverine with genital and audiovisual sexual stimulation. Peak flow and end diastolic velocity were measured in the recorded waveforms obtained 0, 1, 5, 10 and 20 min after injection. The patients also underwent color Doppler ultrasound after a 10-mg oral dose of vardenafil with genital and audiovisual sexual stimulation and at least 5 days after the prior examination. The same parameters were measured at 30, 45, 60, 75 and 90 min after the drug administration. We compared the results with the values obtained after papaverine injection. RESULTS: After oral vardenafil mean peak flow velocity significantly increased starting at 30 min and achieving a maximum value at 60 min. There were no significant differences in the 2 methods in mean peak velocity 1, 5, 10 and 20 min after papaverine injection, and 30, 45, 60, 75 and 90 min after oral vardenafil administration. Although papaverine injection is the gold standard for penile color Doppler ultrasound, it has severe adverse effects such as prolonged erection which we observed in 3 patients (12.5%) and required pharmacological detumescence. After vardenafil no severe adverse effects were observed. CONCLUSIONS: Vardenafil administration achieved increased peak flow velocity comparable to that after intracavernous papaverine injection. With no prolonged erection vardenafil is a safer alternative compared to more invasive intracavernous injection and is also an alternative for patients who fear injections. |
| | |
Authors:
|
Arslan Ardicoglu; Ercan Kocakoc; Ugur Oktay Tuygun; Zulkif Bozgeyik; Irfan Orhan |
Related Documents
:
|
11384633 - Testicular ultrasonography and extended chromosome analysis in men with nonmosaic kline... 27933 - Testicular blood flow and testosterone concentrations in the spermatic venous blood in ... 18062803 - No hypoperfusion is produced in the epicardium during application of myocardial topical... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Urologia internationalis Volume: 75 ISSN: 0042-1138 ISO Abbreviation: Urol. Int. Publication Date: 2005 |
Date Detail:
|
Created Date: 2005-07-22 Completed Date: 2005-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0417373 Medline TA: Urol Int Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 75-9 Citation Subset: IM |
Copyright Information:
|
2005 S. Karger AG, Basel |
Affiliation:
|
Department of Urology, Firat University School of Medicine, Elazig, Turkey. drarslan@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arteries / drug effects, physiopathology, ultrasonography Blood Flow Velocity / drug effects Drug Administration Routes Erectile Dysfunction / drug therapy*, physiopathology, ultrasonography Follow-Up Studies Humans Imidazoles / administration & dosage, therapeutic use* Male Middle Aged Papaverine / administration & dosage, therapeutic use* Penile Erection / drug effects*, physiology Penis / blood supply, ultrasonography Phosphodiesterase Inhibitors / administration & dosage, therapeutic use* Piperazines / administration & dosage, therapeutic use* Sulfones / administration & dosage, therapeutic use Triazines / administration & dosage, therapeutic use Ultrasonography, Doppler, Color* |
| Chemical | |
Reg. No./Substance:
|
0/Imidazoles; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Sulfones; 0/Triazines; 224785-90-4/vardenafil; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pre-ischemic administration of nitric oxide synthase inhibitors reduced germ cell apoptosis after sp...
Next Document: Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladde...