Document Detail

Effectiveness of vaginally administered oxybutynin on rabbit bladder function.
MedLine Citation:
PMID:  12809928     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To demonstrate the effectiveness of vaginally delivered oxybutynin on bladder function. Oxybutynin has been used for treatment of urge urinary incontinence for more than 20 years. METHODS: Thirty female New Zealand White rabbits were used for this experiment. Each rabbit was anesthetized, and the carotid artery was cannulated for blood pressure monitoring. The bladder dome was catheterized for both monitoring of bladder pressure and cystometry. After initial cystometry, acetylcholine (ACh) was injected into the vesical artery at 15-minute intervals for 4 hours. Cystometry was performed at the 2-hour mark and at the end of each experiment (4 hours). After the third ACh administration, vaginal or oral oxybutynin was given and the effect on the response to ACh, blood pressure, and cystometry was observed. RESULTS: The high dose of oxybutynin completely inhibited the response to ACh and significantly inhibited the micturition reflex. A 45% inhibition of micturition pressure occurred at the intermediate dose. Little effect on compliance after the low dose and a significant increase in compliance after the mid-dose occurred. Both the low and intermediate doses of oxybutynin reduced the response to ACh to approximately 50% of control. No blood pressure effects of vaginal oxybutynin were noted for any concentration. Oral oxybutynin showed very similar effects to that of the intermediate vaginal dose. CONCLUSIONS: Vaginally delivered oxybutynin was effective in decreasing bladder compliance and inhibiting intra-arterial ACh-stimulated bladder contractions with little or no effect on the vascular effect of ACh.
Robert M Levin; Catherine Whitbeck; Abby Borow; Opal Burden; Robert E Leggett
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Urology     Volume:  61     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1273-7     Citation Subset:  IM    
Albany College of Pharmacy, Albany, New York 12208, USA.
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MeSH Terms
Acetylcholine / antagonists & inhibitors,  pharmacology
Administration, Intravaginal
Administration, Oral
Blood Pressure / drug effects
Mandelic Acids / administration & dosage*,  therapeutic use*
Muscle Contraction / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology
Urinary Bladder / drug effects*,  metabolism,  physiology*
Urinary Incontinence / drug therapy,  metabolism
Reg. No./Substance:
0/Mandelic Acids; 51-84-3/Acetylcholine; 5633-20-5/oxybutynin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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