Document Detail

Effectiveness of vagal nerve stimulation (VNS) in patients with drop-attacks and different epileptic syndromes.
MedLine Citation:
PMID:  21396833     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The effectiveness of VNS was evaluated in thirty-nine encephalopatic patients with drug-resistant epilepsy characterized by multiple seizures and drop attacks. Twenty-five patients were affected by severe epilepsy with multiple independent spike foci (SE-MISF) and fourteen patients by Lennox-Gastaut syndrome (LGS).
METHOD: Changes in seizure frequency, cognition, adaptive behaviour and quality of life were assessed before and after VNS implant until three years. Outcome assessment for all seizure types included the number of seizures/month and the reduction in seizure frequency rate at each follow-up. Moreover, the effect of VNS on frequency, duration and intensity of drop attacks was separately addressed by a modification of McHugh scale.
RESULTS: VNS produced a mean seizure rate reduction of 41% at six months, 50% at twelve months, and 54% at thirty-six months. After one year of stimulation, thirteen patients with SE-MISF (52%) and three patients with LGS (21%) showed a reduction above 50% in all seizures' frequency rate. As for drop attacks, eight patients (20%) gained a reduction above 50%, while seven patients (17%) showed a reduction only in intensity and duration. Cognitive level and adaptive behaviour were unchanged, while a better quality of life was reported in half out of the patients.
CONCLUSIONS: VNS had a greater effect in reducing seizures frequency and drop attacks' intensity and duration in SE-MISF patients than LGS patients. An improved quality of life was observed also in those patients who only reduced the intensity and duration of drop attacks.
N Zamponi; C Passamonti; E Cesaroni; R Trignani; F Rychlicki
Related Documents :
3189473 - Treatment of acquired nystagmus with botulinum a toxin.
7574223 - Digitalis-induced visual disturbances with therapeutic serum digitalis concentrations.
22115873 - Brugada syndrome (bs) and syncope: a complex therapeutic issue.
Publication Detail:
Type:  Journal Article     Date:  2011-03-10
Journal Detail:
Title:  Seizure     Volume:  20     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-10-06     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  468-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anticonvulsants / therapeutic use
Child, Preschool
Cognition / physiology
Combined Modality Therapy
Electrodes, Implanted
Epilepsy / complications,  psychology,  therapy*
Middle Aged
Neuropsychological Tests
Quality of Life
Syncope / etiology,  psychology,  therapy*
Treatment Outcome
Vagus Nerve / physiology*
Vagus Nerve Stimulation*
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The "anconeus slide": rotation flap for management of posterior wound complications about the elbow.
Next Document:  Is there a role for partial nephrectomy in patients with metastatic renal cell carcinoma?