Document Detail

Effectiveness of vaccinating household contacts in addition to chemoprophylaxis after a case of meningococcal disease: a systematic review.
MedLine Citation:
PMID:  18559124     Owner:  NLM     Status:  MEDLINE    
SUMMARYWe performed a systematic review to estimate the effectiveness of vaccination, in addition to chemoprophylaxis, in preventing meningococcal disease among household contacts. Medline, EMBASE, EMGM, and EUIBIS were used for data collection. Studies reporting on at least 100 primary cases and on subsequent cases in household settings with follow-up of more than 2 weeks after onset of disease in the primary case were reviewed. A meta-analysis was used to calculate the average attack rate in household contacts given chemoprophylaxis 14-365 days after onset of disease in the primary case. In total, 652 studies were identified, five studies and one unpublished report met the inclusion criteria. The weighted average attack rate was 1.1/1000 household contacts (95% CI 0.7-1.7). This review supports vaccination of household contacts in addition to chemoprophylaxis to reduce the risk of meningococcal disease among household contacts of a case caused by a vaccine-preventable serogroup.
M R Hoek; H Christensen; W Hellenbrand; P Stefanoff; M Howitz; J M Stuart
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2008-06-18
Journal Detail:
Title:  Epidemiology and infection     Volume:  136     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2008-11-18     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1441-7     Citation Subset:  IM    
EPIET-ECDC, Stockholm, Sweden.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Disease Transmission, Infectious / prevention & control*
Family Characteristics
Family Health*
Meningococcal Infections / prevention & control*
Meningococcal Vaccines / administration & dosage*,  immunology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Meningococcal Vaccines

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