| Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. | |
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MedLine Citation:
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PMID: 11377130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty infants, 6 to 36 mo old, with iron-deficiency anemia (hemoglobin < 11 g/dL) were matched and assigned to two groups. One group received FeS0(4) and the other received ferrous bis-glycinate chelate at a dose of 5 mg of Fe daily per kilogram of body weight for 28 d. Both groups had significant hemoglobin increases (P < 0.001), but only the group treated with ferrous bis-glycinate chelate had significant increases (P < 0.005) in plasma ferritin. Apparent iron bioavailabilities were calculated at 26.7% for FeS0(4) and 90.9% for ferrous bis-glycinate chelate. Regression analysis indicated that absorption of both sources of iron were similarly regulated by the body according to changes in hemoglobin. We concluded that ferrous bis-glycinate chelate is the iron of choice for the treatment of infants with iron-deficiency anemia because of its high bioavailability and good regulation. |
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Authors:
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O Pineda; H D Ashmead |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 17 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2002-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 381-4 Citation Subset: IM |
Affiliation:
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Latin American Center for Nutrition and Metabolic Studies, Antigua, Guatemala. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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drug therapy* Biological Availability Child, Preschool Double-Blind Method Female Ferritins / blood Ferrous Compounds / pharmacokinetics, therapeutic use* Glycine / analogs & derivatives*, pharmacokinetics, therapeutic use* Hemoglobins / metabolism Humans Infant Intestinal Absorption Iron / blood, pharmacokinetics Iron Chelating Agents / pharmacokinetics, therapeutic use* Male Regression Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Ferrous Compounds; 0/Hemoglobins; 0/Iron Chelating Agents; 0/bis-glycino iron II; 56-40-6/Glycine; 7439-89-6/Iron; 7720-78-7/ferrous sulfate; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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