| Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients. | |
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MedLine Citation:
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PMID: 19718004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study aims to evaluate the effectiveness of periodontal therapy combined with tacrolimus in the suppression of gingival overgrowth (GO) and the effect on GO of changing from cyclosporin A to tacrolimus. PATIENTS AND METHODS: Sixteen renal transplant patients, averaging 52 years of age, whose kidney function was stable and were receiving treatment with cyclosporin A, were randomly assigned to one of two groups. In the experimental group, patients were instructed in oral hygiene and underwent periodontal treatment, whereas in the control group, only oral hygiene instructions were given. After the first visit and the change of medication from cyclosporine to tacrolimus in both groups, periodic clinical revisions were carried out for 3 months in order to assess the evolution of GO. RESULTS: All patients showed a progressive decrease in GO. There were no statistically significant differences between the two groups (p>0.05). A greater decrease in GO occurred within the first month after changing the medication. CONCLUSIONS: No improved effectiveness in reducing GO was observed for periodontal therapy in combination with tacrolimus. Tacrolimus is an alternative to cyclosporine when attempting to avoid GO in patients with kidney transplants. |
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Authors:
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Laura Párraga-Linares; Nieves Almendros-Marqués; Leonardo Berini-Aytés; Cosme Gay-Escoda |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-09-01 |
Journal Detail:
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Title: Medicina oral, patología oral y cirugía bucal Volume: 14 ISSN: 1698-6946 ISO Abbreviation: Med Oral Patol Oral Cir Bucal Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-11-30 Revised Date: 2009-12-11 |
Medline Journal Info:
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Nlm Unique ID: 101231694 Medline TA: Med Oral Patol Oral Cir Bucal Country: Spain |
Other Details:
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Languages: eng Pagination: e429-33 Citation Subset: D; IM |
Affiliation:
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Barcelona University Dental School, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cyclosporine / therapeutic use Female Gingival Overgrowth / drug therapy* Humans Immunosuppressive Agents / therapeutic use* Kidney Transplantation Male Middle Aged Prospective Studies Tacrolimus / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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