Document Detail

Effectiveness of steroid treatment for hoarseness caused by idiopathic fibrosing mediastinitis: report of a case.
MedLine Citation:
PMID:  16554997     Owner:  NLM     Status:  MEDLINE    
A 65-year-old woman was referred to our department for investigation and treatment of hoarseness. A chest computed tomography (CT) scan showed a mediastinal mass spreading into the aortopulmonary window. This finding and that of flexible laryngoscopy suggested that the hoarseness was being caused by left recurrent nerve involvement resulting in left vocal cord paralysis. Thus, we performed a mediastinoscopic biopsy via a parasternal incision. Pathological examination revealed dense fibrous tissue infiltrated with varied inflammatory cells. Because no etiological pathogen or neoplastic lesion was identified, we diagnosed idiopathic fibrosing mediastinitis and began treating the patient with prednisolone. After a course of treatment, the mediastinal lesion showed a remarkable response. The hoarseness resolved as the lesion became smaller. Laryngoscopy confirmed recuperation of vocal cord function. This report shows that steroid therapy is a treatment option for hoarseness caused by recurrent laryngeal nerve involvement of fibrosing mediastinitis, if administered under close observation.
Hideo Ichimura; Shigemi Ishikawa; Tatsuo Yamamoto; Masataka Onizuka; Yukinori Inadome; Masayuki Noguchi; Yuzuru Sakakibara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  36     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Fibrosis / complications,  pathology
Glucocorticoids / therapeutic use*
Hoarseness / drug therapy*,  etiology
Mediastinitis / complications*,  pathology
Prednisolone / therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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