| Effectiveness of a single fixed dose of rasburicase 3mg in the management of tumour lysis syndrome. | |
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MedLine Citation:
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PMID: 22686734 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tumour lysis syndrome (TLS) is a life-threatening oncological emergency characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia [1,2] due to the rapid lysis of malignant cells, following the initiation of anticancer therapies[3], Traditionally, therapy for TLS involved intensive hydration, urinary alkalinisation and administration of allopurinol [4-6]. Newer guidelines now include rasburicase, with monitoring of electrolytes, white blood cell counts (WCC) and lactate dehydrogenase (LDH) levels. [1,7,8] Rasburicase, a recombinant urate oxidase enzyme, effectively decreases existing serum uric acid (UA) by oxidising it to allantoin which is readily soluble and excretable [3]. © 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
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Authors:
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John Coutsouvelis; Meredith Wiseman; Lisa Hui; Susan Poole; Michael Dooley; Sushrut Patil; Sharon Avery; Andrew Wei; Andrew Spencer |
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Publication Detail:
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Type: LETTER Date: 2012-6-11 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
Affiliation:
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Senior Clinical Pharmacist, Pharmacy Department, Alfred Health, Senior Clinical Lecturer (Adjunct), Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 55 Commercial Road, Melbourne 3004, Australia email: j.coutsouvelis@alfred.org.au Senior Pharmacist, Pharmacy Department, Alfred Health, Research Fellow (adjunct), Faculty of Pharmacy and Pharmaceutical Sciences, 55 Commercial Road, Melbourne 3004, Australia Research student, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Australia, Pharmacy Research Coordinator. Pharmacy Department, Alfred Health, Research Fellow (adjunct), Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 55 Commercial Road, Melbourne 3004, Australia Director of Pharmacy, Pharmacy Department, Alfred Health, Professor of Clinical Pharmacy, Centre for Medication Usage and Safety, Monash University, 55 Commercial Road, Melbourne 3004, Australia Clinical Haematologist, Department of Malignant Haematology and Stem Cell Transplantation, The Alfred Hospital, Department of Medicine, Monash University, 55 Commercial Road, Melbourne 3004, Australia Clinical Haematologist, Department of Malignant Haematology and Stem Cell Transplantation, The Alfred Hospital, 55 Commercial Road, Melbourne 2004, Australia Clinical Haematologist, Department of Malignant Haematology and Stem Cell Transplantation, The Alfred Hospital and Monash University, 55 Commercial Road, Melbourne 2004, Australia, Head of Service, Department of Malignant Haematology and Stem Cell Transplantation, The Alfred Hospital, Professor of Haematology, Faculty of Medicine, Nursing and Health Sciences, Monash University 55 Commercial Road, Melbourne 2004, Australia. |
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