Document Detail


Effectiveness of selenium supplements in a low-selenium area of China.
MedLine Citation:
PMID:  15817859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully. OBJECTIVE: We carried out a supplementation trial in a selenium-deficient population in China to assess the requirement for selenium as selenite and as selenomethionine. DESIGN: One hundred twenty subjects with an average selenium intake of 10 mug/d were randomly assigned and administered tablets containing no selenium or amounts as high as 66 mug Se/d for 20 wk. Plasma was sampled before supplementation and at 4-wk intervals during supplementation and was assayed for the 2 plasma selenoproteins, glutathione peroxidase and selenoprotein P. RESULTS: Full expression of glutathione peroxidase was achieved with 37 mug Se/d as selenomethionine and with 66 mug/d as selenite. Full expression of selenoprotein P was not achieved at the highest doses of either form. CONCLUSIONS: Full expression of selenoprotein P requires a greater selenium intake than does full expression of plasma glutathione peroxidase. This suggests that selenoprotein P is a better indicator of selenium nutritional status than is glutathione peroxidase and that the recommended dietary allowance of selenium, which was set with the use of glutathione peroxidase as the index of selenium status, should be revised. Selenium as selenomethionine had nearly twice the bioavailability of selenium as selenite.
Authors:
Yiming Xia; Kristina E Hill; Daniel W Byrne; Jiayuan Xu; Raymond F Burk
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  81     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-08     Completed Date:  2005-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-34     Citation Subset:  AIM; IM    
Affiliation:
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
China
Diet
Female
Glutathione Peroxidase / blood
Humans
Male
Nutrition Policy
Nutritional Status / drug effects
Proteins / metabolism*
Selenium / administration & dosage,  deficiency,  therapeutic use*
Selenoprotein P
Selenoproteins
Treatment Outcome
Grant Support
ID/Acronym/Agency:
M01 RR-00095/RR/NCRR NIH HHS; P30 DK26657/DK/NIDDK NIH HHS; P30 ES00267/ES/NIEHS NIH HHS; R01 DK58763/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Proteins; 0/Selenoprotein P; 0/Selenoproteins; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase
Comments/Corrections
Comment In:
Am J Clin Nutr. 2006 Feb;83(2):389; author reply 389-90   [PMID:  16470000 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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