Document Detail

Effectiveness and safety of ultrasound-guided foam sclerotherapy for recurrent varicose veins: immediate results.
MedLine Citation:
PMID:  16784324     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effectiveness and safety of ultrasound-guided foam sclerotherapy in treating recurrent varicose veins. METHODS: Between July 2003 and January 2005, 38 outpatients (25 women; median age 59 years, interquartile range 53.5-66.0) with recurrent varicose veins in 45 legs were treated. Ultrasound was used to identify sites of reflux. The Tessari method was used to produce foam using 3% sodium tetradecyl sulphate; up to 6 mL of foam was injected per session under ultrasound control. Results are shown as median (interquartile range). RESULTS: A single sclerotherapy session was adequate in 26 (58%) legs. In 87% of all legs, complete elimination of both varicose veins and all reflux points was achieved. A positive association between the amount of injected foam and CEAP class (r=0.45, p=0.002) and venous clinical severity score (r=0.37, p=0.012) was found. There was a trend for more sclerotherapy sessions [median 2 (1-2)] in legs with incomplete saphenofemoral junction/ great saphenous vein (GSV) ligation or accessory GSV (n=16) to achieve varicose vein ablation versus legs with other primary sites of reflux [median 1 (1-2), p=0.12]. There were no instances of deep vein thrombosis or systemic complications; superficial thrombophlebitis occurred in 6 (8.2%) of the 73 injection sessions. Legs with proximal reflux due to previous incomplete ligation or fed by an incompetent pelvic vein experienced superficial thrombophlebitis more frequently (4/12, 33%) than legs without proximal reflux [1/33 (3%); OR 16, 95% CI 1.6-164, p=0.014]. CONCLUSION: In most patients, ultrasound-guided foam sclerotherapy is a safe treatment for recurrent varicose veins, with an excellent immediate result. However, the presence of proximal reflux may decrease the immediate results and predispose to superficial thrombophlebitis.
Stavros K Kakkos; Dimitrios G Bountouroglou; Mustafa Azzam; Evi Kalodiki; Marios Daskalopoulos; George Geroulakos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  13     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
Vascular Unit, Ealing Hospital and Department of Vascular Surgery, Imperial College, London, UK.
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MeSH Terms
Middle Aged
Retrospective Studies
Sclerosing Solutions / adverse effects,  therapeutic use*
Severity of Illness Index
Sodium Tetradecyl Sulfate / adverse effects,  therapeutic use*
Thrombophlebitis / epidemiology,  etiology
Treatment Outcome
Ultrasonography, Interventional*
Varicose Veins / prevention & control,  therapy*,  ultrasonography
Reg. No./Substance:
0/Sclerosing Solutions; 1191-50-0/Sodium Tetradecyl Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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