Document Detail

Effectiveness of rehabilitation intervention in persons with multiple sclerosis: a randomised controlled trial.
MedLine Citation:
PMID:  18535027     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A stratified, randomised, waitlist controlled study over 12 months assessed the effectiveness of rehabilitation in persons with multiple sclerosis (MS) in an Australian community cohort. METHODS: Patients with definite MS (n = 101) recruited from a tertiary hospital database, randomised to a treatment group (n = 49) for individualised rehabilitation programme or a control waitlist group (n = 52). Functional Independence Measure (FIM) was used to assess "activity" while the Multiple Sclerosis Impact Scale (MSIS-29) and General Health Questionnaire (GHQ-28) assessed "participation" and quality of life (QoL). Assessments were at baseline and 12 months. RESULTS: Analysis of data from 98 patients (treatment n = 48, control n = 50) showed reduced disability in the treatment group, with statistically significant differences in post-treatment FIM motor scores for the two groups (p<0.001). There was a clinical and statistically significant improvement in FIM (motor) total scores (p<0.001), and the FIM motor domains of: transfer (p<0.001), locomotion (p<0.001), self-care (p<0.001) and the FIM cognitive subscale (p<0.016). In the treated group, 70.8% improved compared with 13% of controls. Significantly more patients in the control group deteriorated over the study period (58.7% vs 16.7%; p<0.001). There were no differences between the control and treatment group scores on the MSIS-physical (p = 0.18), MSIS-psychological (p = 0.45) or GHQ subscales. CONCLUSION: An individualised rehabilitation programme reduces disability in persons with MS compared with no intervention. The impact of rehabilitation on QoL needs further evaluation. More information on the effectiveness of the various components of the multidisciplinary rehabilitation programmes are now needed. Australian clinical trials registry: Trials registration number: ACTRNO12605000676617.
F Khan; J F Pallant; C Brand; T J Kilpatrick
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-06-05
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  79     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1230-5     Citation Subset:  IM    
Department of Rehabilitation Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
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MeSH Terms
Brain / pathology*
Disability Evaluation
Disease Progression
Middle Aged
Multiple Sclerosis* / pathology,  physiopathology,  psychology
Physical Therapy Modalities
Psychomotor Disorders / diagnosis*,  physiopathology,  rehabilitation*
Quality of Life / psychology*
Severity of Illness Index

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