Document Detail

Effectiveness of ranitidine 150 mg at bedtime as maintenance therapy for healed gastric ulcers.
MedLine Citation:
PMID:  9001834     Owner:  NLM     Status:  MEDLINE    
As many as 89% of gastric ulcer patients experience ulcer recurrences within 1 year of successful healing with conventional antiulcer therapies. Because ranitidine is effective in the healing of gastric and duodenal ulcers and the maintenance of healed duodenal ulcers, we hypothesized that ranitidine would also be effective in the maintenance of healed gastric ulcers. A 48-week, placebo-controlled, randomized, double-blind, multicenter trial was conducted to compare ranitidine 150 mg administered at bedtime with placebo for the maintenance of healed gastric ulcers. Endoscopies were performed at baseline and repeated after 12, 24, 36, and 48 weeks of treatment. Gastric ulcer recurrence rates at each scheduled endoscopy were significantly lower in patients receiving ranitidine (5%, 13%, 16%, and 19%, respectively) compared with those receiving placebo (20%, 30%, 40%, and 50%, respectively). Compared with placebo, ranitidine was more effective in maintaining healed gastric ulcers regardless of previous gastric ulcer history, smoking status, age (< 65 vs > or = 65 years), or sex. There were no significant differences between the two treatment groups in the number of patients experiencing adverse events or laboratory abnormalities. Ranitidine 150 mg administered at bedtime provides safe and effective treatment for the maintenance of healed gastric ulcers.
S O Sue; D M Dawson; J A Brown; D R Wood; C S Kleoudis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  18     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1175-83     Citation Subset:  IM    
Glaxo Wellcome Inc., Research Triangle Park, North Carolina, USA.
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MeSH Terms
Administration, Oral
Anti-Ulcer Agents / adverse effects,  therapeutic use*
Bed Rest
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Follow-Up Studies
Middle Aged
Ranitidine / adverse effects,  therapeutic use*
Regression Analysis
Stomach Ulcer / pathology,  prevention & control*
Treatment Outcome
Reg. No./Substance:
0/Anti-Ulcer Agents; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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