Document Detail


Effectiveness of radiation therapy in nephrotic syndrome associated with advanced lung cancer.
MedLine Citation:
PMID:  10516496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paraneoplastic nephrotic syndrome is rare, bur occurs mostly in lung cancer. The glomerular lesion usually exhibits membranous nephropathy. Although surgical therapy has been shown to be effective, the treatment of a paraneoplastic nephrotic syndrome has always been a challenge. Currently no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with unresectable lesions. We present 2 cases having paraneoplastic nephrotic syndrome associated with advanced squamous cell carcinoma of the lung. Radiation therapy of the primary tumor effectively caused regression of the paraneoplastic nephrotic syndrome without affecting the renal function. Our results suggest that irradiation can be the first choice in the treatment of nephrotic syndrome, if the primary tumor is unresectable.
Authors:
Y Shikata; Y Hayashi; H Yamazaki; K Shikata; H Makino
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  83     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-22     Completed Date:  1999-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
Affiliation:
Department of Medicine III, Okayama University Medical School, Okayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Edema / radiotherapy
Glomerulonephritis, Membranous / etiology,  radiography,  radiotherapy
Humans
Kidney / pathology
Lung Neoplasms / complications*,  radiography
Male
Middle Aged
Nephrotic Syndrome / etiology*,  radiography,  radiotherapy*
Paraneoplastic Syndromes / radiotherapy
Proteinuria / etiology,  pathology,  radiotherapy
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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