Document Detail

Effectiveness of prophylactic therapy on goiter recurrence in an area with low iodine intake--a sonographic follow-up study.
MedLine Citation:
PMID:  7711428     Owner:  NLM     Status:  MEDLINE    
There is no agreement as to whether or not drug treatment after surgery for nodular goiter is effective in preventing recurrence of goiter. Data about recurrences in areas of marginally low iodine intake (like Germany) vary widely. Therefore, we performed a retrospective study in 104 patients who had been treated surgically because of benign uninodular or multinodular goiter. The mean follow-up period was 6.4 years (minimal 1 year) with at least three examinations. Thyroid ultrasound with volumetric analysis was recorded in each patient. Thirty-two patients did not receive any prophylaxis, 50 patients were treated with L-thyroxine, 17 patients with a combination of L-thyroxine and iodine and 5 patients with iodine alone. Recurrence of goiter was documented in 28.0% of the untreated patients and in 8.9% of the patients on prophylaxis (P < 0.05). The mean increase of thyroid volume was 7.3 ml versus 3.1 ml in patients without versus with prophylactic drug treatment (not significant). No significant correlation was found between the increase of thyroid volume and age of the patients, follow-up time, or initial thyroid volume, respectively. These data clearly demonstrate the effectiveness of prophylactic drug therapy to prevent recurrence of goiter after thyroid surgery in an iodine-deficient area.
A H Rzepka; K Cissewski; T Olbricht; D Reinwein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Clinical investigator     Volume:  72     ISSN:  0941-0198     ISO Abbreviation:  Clin Investig     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-18     Completed Date:  1995-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9207154     Medline TA:  Clin Investig     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  967-70     Citation Subset:  IM    
Abteilung für klinische Endokrinologie, Universitätsklinikum Essen, Germany.
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MeSH Terms
Follow-Up Studies
Goiter, Nodular / prevention & control*,  ultrasonography
Iodine / deficiency,  therapeutic use*
Middle Aged
Retrospective Studies
Thyroxine / therapeutic use*
Reg. No./Substance:
7488-70-2/Thyroxine; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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