Document Detail


Effectiveness of propagermanium treatment in multiple myeloma patients.
MedLine Citation:
PMID:  15522060     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interferon (IFN) is one of several drugs effective in treating multiple myeloma (MM), and propagermanium is an IFN inducer. We report on 10 MM patients who were treated with propagermanium at doses from 10 to 40 mg. Two patients achieved complete remission (CR), two patients achieved partial remission (PR), and the condition of four patients was stable (stable disease, SD). After discontinuation of propagermanium, the status of MM progressed in two patients who were in SD and in two patients who had achieved PR. The administration of propagermanium was restarted in one patient resulting in a decrease in her paraprotein.
Authors:
Yutaka Tsutsumi; Junji Tanaka; Hiroe Kanamori; Mio Musashi; Hiina Minami; Arata Fukushima; Hiroaki Yamato; Nobuyuki Ehira; Takahito Kawamura; Shinji Obara; Nobutaka Ogura; Masahiro Asaka; Masahiro Imamura; Nobuo Masauzi
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of haematology     Volume:  73     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-01-13     Revised Date:  2013-01-28    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. rtsutsu@nyc.odn.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Disease Progression
Female
Humans
Interferon Inducers / therapeutic use*
Male
Middle Aged
Multiple Myeloma / drug therapy*
Myeloma Proteins / analysis
Organometallic Compounds / therapeutic use*
Remission Induction
Treatment Outcome
Chemical
Reg. No./Substance:
0/Interferon Inducers; 0/Myeloma Proteins; 0/Organometallic Compounds; 1Q2P9TO9Q7/proxigermanium

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