Document Detail


Effectiveness of primaquine terminal prophylaxis against late primary attacks of Plasmodium vivax malaria: a case-control study among troops of the Republic of Korea army.
MedLine Citation:
PMID:  15259477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmodium vivax malaria is an important cause of morbidity among troops operating in endemic areas near the Demilitarized Zone in the Republic of Korea (ROK). The ROK Army has been administering antimalarial chemoprophylaxis to those troops at greatest risk of malaria since 1997. The number of recipients increased from 15000 in 1997 to 90000 in 2001. We undertook a case-control study to estimate the effectiveness of primaquine prophylaxis against late primary attacks of P. vivax malaria in ROK Army troops. Microscopically confirmed cases of P. vivax malaria were identified through hospital-based surveillance. Controls were matched by unit. Between 1 November 2001 and 31 May 2002, 68 cases and 137 matched controls with confirmed chemoprophylaxis status were enrolled. The estimated effectiveness of primaquine prophylaxis was 32% (95% CI 23-63%). Our results suggest that the effectiveness of primaquine prophylaxis against late primary attacks of P. vivax malaria may be insufficient for soldiers of the ROK Army.
Authors:
Keeho Park; Jong-Kwon Kang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  97     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2004-07-19     Completed Date:  2004-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-2     Citation Subset:  IM    
Affiliation:
The Armed Forces Medical Command, Department of Preventive Medicine, Seongnam, Republic of Korea. bachism@lycos.co.kr
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimalarials / therapeutic use*
Case-Control Studies
Humans
Korea
Malaria, Vivax / prevention & control*
Middle Aged
Military Personnel*
Primaquine / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antimalarials; 90-34-6/Primaquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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