Document Detail

Effectiveness of pre-emptive metoclopramide infusion in alleviating pain, discomfort and nausea associated with nasogastric tube insertion: a randomised, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  16351674     Owner:  NLM     Status:  MEDLINE    
Aim of this study was to demonstrate that intravenous metoclopramide can reduce pain, nausea and discomfort during nasogastric tube (NGT) insertion in ED. This prospective, randomised, double-blind, placebo-controlled trial was conducted in the university-based ED. One-hundred patients were enrolled. Before NGT insertion, each eligible patient was randomised to one of the two treatment arms: one group received 2 cc of 10 mg IV metoclopramide, whereas others received 2 cc of normal saline. Before and after the procedure, pain, nausea and discomfort were evaluated using 100-mm visual analogue scale (VAS). This study was analysed using the paired sample test, the independent sample test and the chi(2) test. Forty-nine patients received metoclopramide, and 51 received normal saline. Although initial VAS levels elicited for pain, nausea and discomfort were similar, consequent VAS levels of those in the metoclopramide group were significantly lower as compared with those in the normal saline group. The mean differences of VAS levels were statistically significant for three symptoms (p < 0.001). Mean VAS levels of nausea, discomfort and pain during NGT insertion were significantly lower following administration of IV metoclopramide as compared with normal saline.
D N Ozucelik; M A Karaca; B Sivri
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of clinical practice     Volume:  59     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-14     Completed Date:  2006-05-25     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  1422-7     Citation Subset:  IM    
Department of Emergency Medicine, Hacettepe University Medical School, Sihhiye, Ankara, Turkey.
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MeSH Terms
Aged, 80 and over
Antiemetics / therapeutic use*
Double-Blind Method
Gagging / prevention & control
Infusions, Intravenous
Intubation, Gastrointestinal / adverse effects*,  methods
Metoclopramide / therapeutic use*
Middle Aged
Nausea / prevention & control*
Pain / prevention & control*
Pain Measurement
Prospective Studies
Treatment Outcome
Vomiting / prevention & control
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide
Comment In:
Int J Clin Pract. 2006 Jun;60(6):744   [PMID:  16805762 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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