| Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. | |
| | |
MedLine Citation:
|
PMID: 23458393 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance. Photodynamic therapy with topical 5-aminolevulinic acid (ALA) and red light has been introduced. However, the side effects especially pigmentation are common. OBJECTIVE: To study the efficacy and safety of ALA-photodynamic therapy (PDT) with 420-950 nm intense pulsed light (IPL) in Chinese patients with acne vulgaris. METHODS: Forty-one patients with moderate to severe facial acne were randomly assigned to ALA-IPL-PDT group and IPL group. Ten percent topical ALA was applied to patients in the ALA-IPL-PDT group, while placeboes were applied to patients in the IPL group. After 1 h occlusion, all patients were illuminated with 420-950 nm IPL. The patients in both groups had four treatment sessions with 1-week intervals. One week after each treatment and 4, 8, and 12 weeks after four sessions, acne lesion counts and adverse events were observed. RESULTS: Twelve weeks after treatments, mean reductions of global lesion counts of ALA-IPL-PDT group and IPL group were 75.2% and 51.0%, respectively. Mean reductions of inflammatory and non-inflammatory lesion counts in ALA-IPL-PDT group were (83.6 ± 4.1)% and (57.5 ± 6.8)%, respectively. No severe adverse events were observed. CONCLUSION: ALA-IPL-PDT is an effective treatment for moderate to severe acne vulgaris, and side effects are mild and reversible. |
| | |
Authors:
|
Xingyu Mei; Weimin Shi; Yinglan Piao |
Related Documents
:
|
22955253 - Sustained effectiveness of percutaneous tibial nerve stimulation for overactive bladder... 22933493 - Outcome of combined unicompartmental knee replacement and combined or sequential anteri... 12006193 - Locobase repair cream following co2 laser skin resurfacing reduces interstitial fluid o... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Photodermatology, photoimmunology & photomedicine Volume: 29 ISSN: 1600-0781 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2013 Apr |
Date Detail:
|
Created Date: 2013-03-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: England |
Other Details:
|
Languages: eng Pagination: 90-6 Citation Subset: IM |
Copyright Information:
|
© 2013 John Wiley & Sons A/S. |
Affiliation:
|
Dermatology Department, Shanghai First People's Hospital, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protective effect of mango (Mangifera indica L.) against UVB-induced skin aging in hairless mice.
Next Document: Two cases of eczematid-like purpura of Doucas and Kapetanakis responsive to narrow band ultraviolet ...