Document Detail


Effectiveness and persistence of a topical treatment for cervical ectropion with deoxyribonucleic acid.
MedLine Citation:
PMID:  16170291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of this study was to estimate short and long term effectiveness of a topical treatment for cervical ectropion with 5 mg of deoxyribonucleic acid (DRNA). METHODS: A randomized case-control study was carried out. Two-hundred and twenty patients, colposcopically diagnosed with cervical ectropion, were consecutively enrolled and randomly divided into 2 groups: treated (group 1) and controls (group 2). The therapeutic plan consisted of DRNA 5 mg vaginal suppositories, administered for 15 days monthly; subsequently posology was reduced gradually. Both groups underwent a clinical and colposcopical follow-up on the 1st, 4th, 10th and 22nd months after the first examination. At the end of the study, the size of ectropion was considered a parameter of re-epithelialization and provided a criterion of treatment effectiveness. According to this protocol, subjects were defined improved, stable or worsened. Statistical analysis including Pearson chi2 tests, Fisher's exact tests, Yate's corrected chi2 and relative-risk (95% CI) was performed. RESULTS: Of the 220 enrolled patients, 140 completed the study protocol: 76 treated and 64 controls. Outcomes after treatment and follow-up consisted of: 74 (97.4%) improved in group 1, against 2 cases (3.1%) in group 2. High statistical significance was reported comparing outcome frequencies in the 2 groups (P<0.0001). CONCLUSIONS: This study shows a significant reduction (P<0.0001) in cervical ectropion size between cases (topical treatment with DRNA 5 mg) and controls. A follow-up of 22 months confirmed the persistence and effectiveness of this medical approach.
Authors:
P Belfiore; E Costa; S De Cantis; R Vassallo; A Marino
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Minerva ginecologica     Volume:  57     ISSN:  0026-4784     ISO Abbreviation:  Minerva Ginecol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2005-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400731     Medline TA:  Minerva Ginecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  461-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University Polyclinic, Palermo, Italy. pinabelfiore@tiscali.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Colposcopy
DNA / administration & dosage,  therapeutic use
Data Interpretation, Statistical
Female
Follow-Up Studies
Humans
Middle Aged
Suppositories
Time Factors
Treatment Outcome
Uterine Cervical Diseases / diagnosis,  drug therapy*
Chemical
Reg. No./Substance:
0/Suppositories; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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