| Effectiveness and persistence of a topical treatment for cervical ectropion with deoxyribonucleic acid. | |
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MedLine Citation:
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PMID: 16170291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to estimate short and long term effectiveness of a topical treatment for cervical ectropion with 5 mg of deoxyribonucleic acid (DRNA). METHODS: A randomized case-control study was carried out. Two-hundred and twenty patients, colposcopically diagnosed with cervical ectropion, were consecutively enrolled and randomly divided into 2 groups: treated (group 1) and controls (group 2). The therapeutic plan consisted of DRNA 5 mg vaginal suppositories, administered for 15 days monthly; subsequently posology was reduced gradually. Both groups underwent a clinical and colposcopical follow-up on the 1st, 4th, 10th and 22nd months after the first examination. At the end of the study, the size of ectropion was considered a parameter of re-epithelialization and provided a criterion of treatment effectiveness. According to this protocol, subjects were defined improved, stable or worsened. Statistical analysis including Pearson chi2 tests, Fisher's exact tests, Yate's corrected chi2 and relative-risk (95% CI) was performed. RESULTS: Of the 220 enrolled patients, 140 completed the study protocol: 76 treated and 64 controls. Outcomes after treatment and follow-up consisted of: 74 (97.4%) improved in group 1, against 2 cases (3.1%) in group 2. High statistical significance was reported comparing outcome frequencies in the 2 groups (P<0.0001). CONCLUSIONS: This study shows a significant reduction (P<0.0001) in cervical ectropion size between cases (topical treatment with DRNA 5 mg) and controls. A follow-up of 22 months confirmed the persistence and effectiveness of this medical approach. |
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Authors:
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P Belfiore; E Costa; S De Cantis; R Vassallo; A Marino |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Minerva ginecologica Volume: 57 ISSN: 0026-4784 ISO Abbreviation: Minerva Ginecol Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-09-19 Completed Date: 2005-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400731 Medline TA: Minerva Ginecol Country: Italy |
Other Details:
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Languages: eng Pagination: 461-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Polyclinic, Palermo, Italy. pinabelfiore@tiscali.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Colposcopy DNA / administration & dosage, therapeutic use Data Interpretation, Statistical Female Follow-Up Studies Humans Middle Aged Suppositories Time Factors Treatment Outcome Uterine Cervical Diseases / diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Suppositories; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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