| Effectiveness of ototopical antibiotics for chronic suppurative otitis media in Aboriginal children: a community-based, multicentre, double-blind randomised controlled trial. | |
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MedLine Citation:
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PMID: 12914507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the effectiveness of ototopical ciprofloxacin (0.3%; CIP) with framycetin (0.5%), gramicidin, dexamethasone (FGD) eardrops (5 drops twice daily for 9 days) together with povidone-iodine (0.5%) ear cleaning as treatments for chronic suppurative otitis media (CSOM) in Aboriginal children. DESIGN AND PARTICIPANTS: Aboriginal community-controlled, community-based, multicentre, double-blind, randomised controlled trial in eight Aboriginal Community Controlled Health Services across northern Australia, involving 147 Aboriginal children with CSOM. MAIN OUTCOME MEASURES: Resolution of otorrhoea (clinical cure), proportion of children with healed perforated tympanic membrane (TM) and improved hearing, 10-21 days after starting treatment. RESULTS: 111 children aged 1-14 years (CIP, 55; FGD, 56) completed treatment. CSOM cures occurred in 64% (CIP, 76.4%; FGD, 51.8%), with a significantly higher rate in the ciprofloxacin group (P = 0.009, absolute difference of 24.6% [95% CI, 15.8%-33.4%]). TM perforation size and the level of hearing impairment did not change. Pseudomonas aeruginosa was the most common bacterial pathogen (in 47.6%), while respiratory pathogens were rare (in 5.7%). CONCLUSIONS: Twice-daily ear cleaning and topical ciprofloxacin is effective at community-level in achieving cure for CSOM. Healthcare providers to Aboriginal children with CSOM should be given special access to provide ototopical ciprofloxacin as first-line treatment. |
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Authors:
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Sophie Couzos; Traven Lea; Reinhold Mueller; Richard Murray; Margaret Culbong |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Medical journal of Australia Volume: 179 ISSN: 0025-729X ISO Abbreviation: Med. J. Aust. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-13 Completed Date: 2003-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400714 Medline TA: Med J Aust Country: Australia |
Other Details:
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Languages: eng Pagination: 185-90 Citation Subset: IM |
Affiliation:
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National Aboriginal Community Controlled Health Organisation, PO Box 168, Deakin, ACT 2600, Australia. scouzos@tpgi.com.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Anti-Infective Agents / administration & dosage* Child Child, Preschool Chronic Disease Ciprofloxacin / administration & dosage Community Health Services Dexamethasone / administration & dosage Drug Administration Schedule Female Framycetin / administration & dosage Gramicidin / administration & dosage Humans Infant Male Oceanic Ancestry Group Otitis Media, Suppurative / drug therapy*, pathology Povidone-Iodine / administration & dosage Queensland Treatment Outcome Western Australia |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 119-04-0/Framycetin; 1405-97-6/Gramicidin; 25655-41-8/Povidone-Iodine; 50-02-2/Dexamethasone; 85721-33-1/Ciprofloxacin |
| Comments/Corrections | |
Comment In:
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Med J Aust. 2004 Jul 19;181(2):84
[PMID:
15257644
]
Med J Aust. 2004 Jan 19;180(2):91-2; author reply 92-3 [PMID: 14768072 ] Med J Aust. 2004 Jan 19;180(2):91; author reply 92-3 [PMID: 14723593 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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