| Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea. | |
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MedLine Citation:
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PMID: 19122308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Central sleep apnea, often found in patients with chronic heart failure (CHF), has a high risk of poor prognosis. METHODS AND RESULTS: This study involved 20 patients with CHF (left ventricular ejection fraction (LVEF) <45%, M/F =19/1, age 65+/-10 years) and an apnea-hypopnea index (AHI) >5 times/h who were divided into 2 groups: 10 patients treated with nocturnal home oxygen therapy (HOT) and 10 patients without HOT (non-HOT). All patients had dilated cardiomyopathy and underwent overnight polysomnography, cardiopulmonary exercise testing, and nuclear cardiac examinations to evaluate AHI, exercise capacity according to the specific activity scale and oxygen uptake at anaerobic threshold and peak exercise (peak VO(2)). Cardiac function according to (99m)Tc-MIBI QGS, and the total defect score (TDS), H/M ratio and the washout rate (WR) on (123)I-metaiodobenzylguanidine (MIBG) imaging were calculated for all patients. As compared with the non-HOT group, the HOT group demonstrated a greater reduction in AHI (26.1+/-9.1 to 5.1+/-3.4), (123)I-MIBG TDS (31+/-8 to 25+/-9), and (123)I-MIBG WR (48+/-8% to 41+/-5%) and a greater increase in the specific activity scale (4.0+/-0.9 to 5.8+/-1.2 Mets), peak VO(2) (16.0+/-3.8 to 18.3+/-4.7 ml . min(-1) . kg(-1)), and LVEF (27+/-9% to 37+/-10%). CONCLUSIONS: HOT improves exercise capacity, cardiac function, and cardiac sympathetic nerve activity in patients with CHF and central sleep apnea. |
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Authors:
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Takuji Toyama; Ryotaro Seki; Shu Kasama; Naoki Isobe; Shigeki Sakurai; Hitoshi Adachi; Hiroshi Hoshizaki; Shigeru Oshima; Koichi Taniguchi |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2008-12-27 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Affiliation:
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Gunma Prefectural Cardiovascular Center, Maebashi, Japan. toyama.t@cvc.pref.gunma.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ambulatory Care / methods* Chronic Disease Exercise Tolerance / physiology* Female Follow-Up Studies Heart / innervation*, radionuclide imaging Heart Failure / complications, physiopathology* Humans Male Middle Aged Oxygen Consumption / physiology Oxygen Inhalation Therapy / methods* Sleep Apnea, Central / etiology, physiopathology* Stroke Volume / physiology Sympathetic Nervous System / physiology* Tomography, Emission-Computed, Single-Photon Treatment Outcome |
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