| Effectiveness of nitric oxide during spontaneous breathing in experimental lung injury. | |
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MedLine Citation:
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PMID: 20337573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inhaled nitric oxide (iNO) improves gas exchange in about 60% of patients with acute respiratory distress syndrome (ARDS). Recruitment of atelectatic lung areas may improve responsiveness and preservation of spontaneous breathing (SB) may cause recruitment. Accordingly, preservation of SB may improve effectiveness of iNO. To test this hypothesis, iNO was evaluated in experimental acute lung injury (ALI) during SB. In 24 pigs with ALI, effects of 10 ppm iNO were evaluated during controlled mechanical ventilation (CMV) and SB in random order. Preservation of SB was provided by 4 different modes: Unassisted SB was enabled by biphasic positive airway pressure (BIPAP), moderate inspiratory assist was provided by pressure support (PS) and volume-assured pressure support (VAPS), maximum assist was ensured by assist control (A/C). Statistical analysis did not reveal gas exchange improvements due to SB alone. Significant gas exchange improvements due to iNO were only achieved during unassisted SB with BIPAP (P <.05) but not during CMV or assisted SB. The authors conclude that effectiveness of iNO may be improved by unassisted SB during BIPAP but not by assisted SB. Thus combined iNO and unassisted SB is possibly most effective to improve gas exchange in severe hypoxemic ARDS. |
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Authors:
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Rolf Dembinski; Nadine Hochhausen; Sandra Terbeck; Johannes Bickenbach; Frederik Stadermann; Rolf Rossaint; Ralf Kuhlen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental lung research Volume: 36 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: England |
Other Details:
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Languages: eng Pagination: 159-66 Citation Subset: IM |
Affiliation:
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Department of Surgical Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany. rolf.dembinski@post.rwth-aachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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drug therapy,
physiopathology,
therapy* Administration, Inhalation Animals Anoxia / physiopathology, therapy Disease Models, Animal Female Hemodynamics / drug effects Nitric Oxide / administration & dosage* Positive-Pressure Respiration Pulmonary Gas Exchange / drug effects Respiration / drug effects* Respiration, Artificial* / methods Respiratory Mechanics / drug effects Swine |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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