| Effectiveness of a new calcium antagonist in severe hypertension. | |
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MedLine Citation:
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PMID: 3793949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrendipine is a new nifedipine-like calcium antagonist antihypertensive agent. In this study, nitrendipine 5-40 mg orally bid was administered for up to three months to 16 patients with severe essential hypertension (untreated supine diastolic blood pressure greater than or equal to 115 mm Hg). Hydrochlorothiazide or propranolol or both were also given to patients who did not achieve goal blood pressure with nitrendipine alone. Five patients achieved goal blood pressure (supine less than or equal to 90 mm Hg) with nitrendipine alone and six more after the addition of a second drug, and only four required triple-drug therapy. One patient was terminated from the study because of headaches, a common nitrendipine side effect. This study demonstrates that nitrendipine is an effective and well-tolerated agent in the treatment of severe hypertension. |
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Authors:
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J F Burris; R P Santangelo; W J Mroczek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 26 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1986 Nov-Dec |
Date Detail:
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Created Date: 1987-02-04 Completed Date: 1987-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 593-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects Female Heart Rate / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Nitrendipine / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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39562-70-4/Nitrendipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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