| Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet. | |
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MedLine Citation:
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PMID: 19345713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was carried out to determine the ability of dietary micronized wheat fibres (MWF) to decrease the levels of ochratoxin A (OTA) in plasma, kidney and liver of piglets fed a naturally contaminated diet. A total of 96 piglets (weighting 11.4+/-1.5 kg) were fed one of four different diets for 28 days. Diets included (1) control diet, (2) control diet with MWF (1%), (3) OTA naturally contaminated diet (117.45+/-4.74 ng/g), (4) OTA naturally contaminated diet (118.13+/-2.85 ng/g) with MWF (1%). No difference in feed efficiency (P>0.05) could be observed between the different diets. The absolute weight of kidneys and liver were significantly higher in pigs fed the OTA-contaminated diet (diet 3) as compared to the control diet (diet 1) or to the control diet amended with MWF (diet 2) (P<0.05). However the use of MWF (diet 4) significantly protected against these weight changes. A significant protective effect of MWF was also observed in terms of OTA concentration in plasma (45.6% decrease), kidney (40.8% decrease) and liver (26.5% decrease). These results suggest that the addition of MWF is effective in decreasing the bioavailability of OTA from contaminated diets in piglets. |
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Authors:
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N Aoudia; P Callu; F Grosjean; Y Larondelle |
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Publication Detail:
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Type: Journal Article Date: 2009-04-05 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 47 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1485-9 Citation Subset: IM |
Affiliation:
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Unité de Biochimie de la Nutrition, Faculté d'Ingénierie Biologique, Agronomique et Environnementale, Croix du sud 8/02, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
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analysis Animals Carcinogens / pharmacokinetics* Chromatography, Affinity Diet Dietary Fiber / pharmacology* Female Food Contamination / analysis Growth / drug effects Immunochemistry Kidney / drug effects, metabolism* Liver / drug effects, metabolism* Male Mycotoxins / metabolism* Ochratoxins / blood, pharmacokinetics* Organ Size / drug effects Swine Tissue Distribution Triticum / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Mycotoxins; 0/Ochratoxins; 303-47-9/ochratoxin A |
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