Document Detail


Effectiveness of mesothelin family proteins and osteopontin for malignant mesothelioma.
MedLine Citation:
PMID:  22835614     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Malignant mesothelioma is an aggressive tumour with poor prognosis whose early diagnosis is difficult. Mesothelin, megakaryocyte potentiating factor and osteopontin have attracted attention. The aim of the present study is to provide an overview regarding these candidate biomarkers for malignant mesothelioma, and discuss their potential role in today's clinical practice.Mesothelin and megakaryocyte potentiating factor have a good specificity but a sub-optimal sensitivity for malignant mesothelioma detection being negative in sarcomatoid histologic subtype and in almost half of epithelioid mesothelioma, especially in the early stages. Osteopontin is a marker of the duration of asbestos exposure, but lacks specificity for mesothelioma. Several patient characteristics influence diagnostic accuracy of biomarkers and make the establishment of the "optimal" diagnostic threshold difficult. Mesothelin and megakaryocyte potentiating factor have proved useful in assessing response to treatment. Combining different markers together may lead to an improvement in diagnostic accuracy but there is still need for research in this area. Extensive validation and further research is required to improve the use of serum markers in mesothelioma management. In the nearby future, their application in clinical practice is likely most situated in monitoring response to therapy, rather than in guiding diagnostic decisions and risk assessment of asbestos-exposed populations.
Authors:
Ioannis Pantazopoulos; Boura Paraskevi; Theodoros Xanthos; Syrigos Konstantinos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-26
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Sotiria General Hospital, Athens, Greece.
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