Document Detail

Effectiveness of maintenance bee venom immunotherapy administered at 6-month intervals.
MedLine Citation:
PMID:  17941283     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Extension of the intervals at which maintenance venom immunotherapy (MVIT) is administered has been attempted for many years. However, published evidence on its effect, especially in intervals of longer than 3 months, is sparse. OBJECTIVE: To examine whether the administration of a bee venom (BV) maintenance dose at 6-month intervals is safe and efficacious. METHODS: The 3-month intervals at which venom-allergic patients were receiving their MVIT were gradually extended to 6 months. Systemic reactions (SRs) to immunotherapy injections or to field stings were regularly recorded. Patients who were allergic to BV alone or also to other venoms were deliberately sting challenged by a honeybee after reaching the 6-month interval. RESULTS: The 3-month intervals were extended in 47 patients. A single patient (2%) developed an SR after receiving the injection at an interval of 4 months. Two field stings in 2 patients resulted in a mild SR in 1 patient. Of 14 sting-challenged patients, 3 (21%) developed an SR after the challenge. The 3 SRs occurred only among the 8 patients (38%) who were allergic to BV alone. The 3 patients with the SR to the challenge continued to receive the regular maintenance dose at monthly intervals 3 to 5 more times. Repeated sting challenges were then well tolerated in all 3 patients. CONCLUSION: The administration of MVIT at 6-month intervals does not provide suitable protection in BV-allergic patients, and they should continue MVIT at the accepted 1- to 3-month intervals.
Arnon Goldberg; Ronit Confino-Cohen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  99     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-18     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Allergy and Clinical Immunology Unit, Meir Hospital, Kfar-Saba, Israel.
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MeSH Terms
Bee Venoms / administration & dosage*,  immunology,  therapeutic use
Desensitization, Immunologic / methods*
Hypersensitivity, Immediate / immunology,  prevention & control*
Insect Bites and Stings / immunology
Middle Aged
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Bee Venoms

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