| Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study. | |
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MedLine Citation:
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PMID: 15960629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are anecdotal reports of increased effectiveness of allergen-specific immunotherapy (ASIT) in dogs with doses of vaccine lower than that recommended by the manufacturers. However, no controlled studies have been carried out. The aim of this prospective, double-blinded study was to evaluate whether induction and maintenance with low dose (LD) ASIT resulted in a different success rate compared with the standard dose (SD). Twenty-seven dogs with confirmed atopic dermatitis were allocated by block randomization to two groups. One group (n = 13) received SD ASIT; the other group (n = 14) received LD ASIT (1/10 of the SD) following the same frequency protocol. Cases were graded at 0, 3, 6 and 9 months for clinical signs using a modified canine atopic dermatitis extent and severity index (mCADESI) and for pruritus using a 0-5 descriptor scale. There were no significant differences between the groups in the pruritus and mCADESI scores (P > 0.155) at the end of the study, and the changes in pruritus (P > 0.920) and mCADESI (P > 0.296) scores from the beginning to the end of the study were similar in both groups. Pruritus scores in both groups did not change during the study (P > 0.052). However, significant reductions in mCADESI scores were seen in both groups (P < 0.032). Six dogs achieved a final pruritus score of 0, six achieved a reduction in pruritus score and 15 did not improve or worsened. There was, therefore, no evidence that LD ASIT is more effective than the standard protocol. |
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Authors:
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Silvia Colombo; Peter B Hill; Darren J Shaw; Keith L Thoday |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Veterinary dermatology Volume: 16 ISSN: 0959-4493 ISO Abbreviation: Vet. Dermatol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-17 Completed Date: 2005-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9426187 Medline TA: Vet Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 162-70 Citation Subset: IM |
Affiliation:
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Dermatology Unit, The University of Edinburgh, The Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland, UK. colombo_silvia@yahoo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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administration & dosage* Animals Dermatitis, Atopic / drug therapy, veterinary* Desensitization, Immunologic / veterinary* Dog Diseases / drug therapy*, pathology Dogs Double-Blind Method Female Injections / veterinary Male Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Allergens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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