Document Detail


Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study.
MedLine Citation:
PMID:  15960629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are anecdotal reports of increased effectiveness of allergen-specific immunotherapy (ASIT) in dogs with doses of vaccine lower than that recommended by the manufacturers. However, no controlled studies have been carried out. The aim of this prospective, double-blinded study was to evaluate whether induction and maintenance with low dose (LD) ASIT resulted in a different success rate compared with the standard dose (SD). Twenty-seven dogs with confirmed atopic dermatitis were allocated by block randomization to two groups. One group (n = 13) received SD ASIT; the other group (n = 14) received LD ASIT (1/10 of the SD) following the same frequency protocol. Cases were graded at 0, 3, 6 and 9 months for clinical signs using a modified canine atopic dermatitis extent and severity index (mCADESI) and for pruritus using a 0-5 descriptor scale. There were no significant differences between the groups in the pruritus and mCADESI scores (P > 0.155) at the end of the study, and the changes in pruritus (P > 0.920) and mCADESI (P > 0.296) scores from the beginning to the end of the study were similar in both groups. Pruritus scores in both groups did not change during the study (P > 0.052). However, significant reductions in mCADESI scores were seen in both groups (P < 0.032). Six dogs achieved a final pruritus score of 0, six achieved a reduction in pruritus score and 15 did not improve or worsened. There was, therefore, no evidence that LD ASIT is more effective than the standard protocol.
Authors:
Silvia Colombo; Peter B Hill; Darren J Shaw; Keith L Thoday
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary dermatology     Volume:  16     ISSN:  0959-4493     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-17     Completed Date:  2005-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  162-70     Citation Subset:  IM    
Affiliation:
Dermatology Unit, The University of Edinburgh, The Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland, UK. colombo_silvia@yahoo.it
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MeSH Terms
Descriptor/Qualifier:
Allergens / administration & dosage*
Animals
Dermatitis, Atopic / drug therapy,  veterinary*
Desensitization, Immunologic / veterinary*
Dog Diseases / drug therapy*,  pathology
Dogs
Double-Blind Method
Female
Injections / veterinary
Male
Prospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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