| Effectiveness of low dose cyclosporine in acquired aplastic anaemia with severe neutropenia. | |
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MedLine Citation:
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PMID: 1470285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six patients with acquired aplastic anaemia were treated with cyclosporine (5 mg/kg/day) either alone or in combination with corticosteroids. A favourable response was observed in 4, including 2 patients presenting with an absolute granulocyte count of less than 0.2 x 10(9)/l. The 6th patient showed no effect after 6 wk of therapy and was thereafter successfully treated with anti-thymocyte globulin (ATG). Side effects of cyclosporine therapy were minimal (maximum follow-up 20 months). Temporary discontinuation of the drug in 1 patient resulted in a relapse which responded to reinstitution of therapy. Our results indicate that cyclosporine may be an effective, well-tolerated agent in acquired aplastic anaemia even in previously untreated patients with severe neutropenia. |
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Authors:
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O C Leeksma; L L Thomas; J van der Lelie; M H van Oers; A E von dem Borne; R Goudsmit |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Netherlands journal of medicine Volume: 41 ISSN: 0300-2977 ISO Abbreviation: Neth J Med Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-01-27 Completed Date: 1993-01-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0356133 Medline TA: Neth J Med Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 143-8 Citation Subset: IM |
Affiliation:
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Department of Haematology, Academic Medical Centre, Amsterdam, Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia, Aplastic / blood, complications, drug therapy* Cyclosporine / therapeutic use* Drug Therapy, Combination Female Humans Male Middle Aged Neutropenia / complications Prednisolone / therapeutic use Prednisone / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-24-8/Prednisolone; 53-03-2/Prednisone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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