Document Detail

Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI).
MedLine Citation:
PMID:  2868337     Owner:  NLM     Status:  MEDLINE    
In an unblinded trial of intravenous streptokinase (SK) in early acute myocardial infarction, 11 806 patients in one hundred and seventy-six coronary care units were enrolled over 17 months. Patients admitted within 12 h after the onset of symptoms and with no contraindications to SK were randomised to receive SK in addition to usual treatment and complete data were obtained in 11 712. At 21 days overall hospital mortality was 10.7% in SK recipients versus 13% in controls, an 18% reduction (p = 0.0002, relative risk 0.81). The extent of the beneficial effect appears to be a function of time from onset of pain to SK infusion (relative risks 0.74, 0.80, 0.87, and 1.19 for the 0-3, 3-6, 6-9, and 9-12 h subgroups). SK seems to be a safe drug for routine administration in acute myocardial infarction.
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-20     Completed Date:  1986-03-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiovascular Agents / therapeutic use
Clinical Trials as Topic
Follow-Up Studies
Infusions, Parenteral
Myocardial Infarction / drug therapy*,  mortality
Prospective Studies
Random Allocation
Streptokinase / administration & dosage,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Cardiovascular Agents; EC 3.4.-/Streptokinase

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