Document Detail

Effectiveness of intravenous streptokinase on infarct size and left ventricular function in acute myocardial infarction. Prospective and randomized study.
MedLine Citation:
PMID:  3301120     Owner:  NLM     Status:  MEDLINE    
Within 3 h after the onset of symptoms of myocardial infarction, 64 patients were randomly assigned to receive either a 1-h intravenous infusion of 1,500,000 IU of streptokinase (SK) or a conventional therapy. Infarct size was estimated in CK gram equivalent (CKg) by measurement of CK-MB every 3 hours during a 48-h period. Enzymatic study revealed that myocardial infarction of the SK group was significantly smaller (61.4 +/- 45 vs. 89.4 +/- 56 CKg, p less than .05). Angiograms were performed at early stage and five weeks after myocardial infarction. At first coronary angiogram, the infarct-related vessel was open in 82% in the SK group versus 12% in controls. The SK group had higher global ejection fraction at second angiogram (57 +/- 11% vs. 49 +/- 11%, p less than .02), but differences in regional wall motion were not significant. By analysis according to patency or occlusion of infarct-related vessel, global and regional ejection fractions were significantly better at first and at second angiograms in all patients and in anterior infarctions with a patent infarct-related coronary artery. There was no significant difference for inferior infarction. We conclude that intravenous streptokinase infusion early after the onset of myocardial infarction reduces infarct size and improves left ventricular function, chiefly in anterior infarction. This benefit appears to be closely correlated to patency of infarct-related vessels.
P Durand; P Asseman; P Pruvost; M E Bertrand; J M LaBlanche; C Thery
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical cardiology     Volume:  10     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-11     Completed Date:  1987-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-92     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Clinical Enzyme Tests
Clinical Trials as Topic
Creatine Kinase / blood
Middle Aged
Myocardial Infarction / diagnosis,  drug therapy*
Prospective Studies
Random Allocation
Streptokinase / therapeutic use*
Stroke Volume
Reg. No./Substance:
0/Isoenzymes; EC Kinase; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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