| Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. | |
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MedLine Citation:
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PMID: 15235345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the effectiveness of intratympanic dexamethasone (IT-DEX) in patients with severe or profound sudden sensorineural hearing loss (SSNHL) after treatment failure with conventional therapy. STUDY DESIGN: Randomized, controlled study. METHODS: Patients who met the criteria for SSNHL, with a severity of severe to profound, underwent 10 days of standard treatment with oral steroid and other facilitating agents. Patients showing poor response to standard treatment were assigned randomly to a control group or to a group receiving IT-DEX. IT-DEX injections were performed once a week for 3 consecutive weeks. Pure-tone audiometry was obtained before each injection. Minimum follow-up time was 1 month. Successful treatment was defined as a hearing improvement of greater than 30 dB. RESULTS: Thirty-nine patients meeting the inclusion criteria were studied. After treatment with oral steroid, 10 of 39 (26%) patients demonstrated hearing improvement, whereas the remaining 29 (74%) patients showed a hearing improvement of less than 30 dB. For those without hearing improvement, 15 received IT-DEX, and 14 received further standard treatment (except oral steroid and carbogen inhalation). Hearing improved in 8 of 15 (53.3%) compared with 1 of 14 (7.1%), with an average decrease in threshold of 28.4 dB and 13.2 dB for the IT-DEX group and the control group, respectively (P <.05). Prognostic factors such as age, treatment delay time, and sex did not significantly affect the response to therapy. CONCLUSIONS: IT-DEX injection effectively improves hearing in patients with severe or profound SSNHL after treatment failure with standard therapy and is not associated with major side effects. It is therefore a reasonable alternative as salvage treatment. |
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Authors:
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Ho Guan-Min Ho; Hung-Ching Lin; Min-Tsan Shu; Cheng-Chien Yang; Hsun-Tien Tsai |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Laryngoscope Volume: 114 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-05 Completed Date: 2004-08-26 Revised Date: 2005-03-07 |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 1184-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Mackay Memorial Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents / administration & dosage, therapeutic use* Audiometry, Pure-Tone Chi-Square Distribution Child Dexamethasone / administration & dosage, therapeutic use* Hearing Loss, Sudden / drug therapy* Humans Injections Middle Aged Salvage Therapy Treatment Outcome Tympanic Membrane |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone |
| Comments/Corrections | |
Comment In:
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Laryngoscope. 2005 Feb;115(2):378; author reply 378-9
[PMID:
15689773
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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