| Effectiveness of interventions for reducing diabetes and cardiovascular disease risk in people with metabolic syndrome: systematic review and mixed treatment comparison meta-analysis. | |
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MedLine Citation:
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PMID: 22284386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To review the evidence on interventions for reversing metabolic syndrome or preventing development of type 2 diabetes and cardiovascular disease in people with metabolic syndrome. Methods: A systematic review and Bayesian mixed treatment comparison meta-analysis was conducted. Relevant electronic bibliographic databases were searched up to January 2010. Included studies were randomised controlled trials with a follow-up of >24 weeks and outcomes comparing incidence of diabetes and/or cardiovascular disease, or reversal of metabolic syndrome. Results: 16 studies met the inclusion criteria. 13 studies with outcome data for reversal of metabolic syndrome, involving 3907 participants, were included in the meta-analysis. Insufficient trials reported cardiovascular events/mortality, or incidence of type 2 diabetes, to conduct a meta-analysis for these outcomes. Interventions, alone or in combination, included lifestyle (diet and/or exercise) and pharmacological therapy. Using random effects models, both lifestyle (OR 3.81; 95% CI 2.47-5.88) and pharmacological interventions (OR 1.59; 95% CI 1.04-2.45) were statistically superior compared to control for reversing metabolic syndrome. Using mixed treatment comparison methods the probability that lifestyle interventions were the most clinically effective was 87%. Conclusions: Evidence suggests that both lifestyle and pharmacological interventions can reverse metabolic syndrome. However, there is a lack of data on whether these benefits are sustained and translate into longer term prevention of diabetes and/or cardiovascular disease. |
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Authors:
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Alison J Dunkley; Kathryn Charles; Laura J Gray; Janette Camosso-Stefinovic; Melanie J Davies; Kamlesh Khunti |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Research Associate in Nursing, Department of Health Sciences, University of Leicester. Practice Manager, The Grove Medical Practice, Northolt, Middlesex. Lecturer in Population and Public Health Sciences, Department of Health Sciences, University of Leicester. Information Librarian, Department of Health Sciences, University of Leicester. Professor of Diabetes Medicine, Department of Cardiovascular Sciences, University of Leicester. Professor of Primary Care Diabetes & Vascular Medicine, Department of Health Sciences, University of Leicester. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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