Document Detail


Effectiveness of inspiratory pressure-limited approach to mechanical ventilation in septic patients.
MedLine Citation:
PMID:  22523366     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Severe sepsis is one of the most common causes of acute lung injury (ALI) and is associated with high mortality. The aim of the study was to see if a protective strategy based approach with a plateau pressure < 30 cm H2O was associated with lower mortality in septic patients with ALI in the Surviving Sepsis Campaign (SSC) international database.A retrospective analysis of an international multicentric database of 15,022 septic patients from the 165 ICUs was used. Septic patients with ALI and mechanical ventilation (n=1,738) had more accompanying organ dysfunction and a higher mortality rate (48.3 vs. 33.0%; p<0.001) than septic patients without ALI (n=13,284). In patients with ALI and mechanical ventilation, the use of a inspiratory plateau pressures maintained < 30 cm H2O was associated with lower mortality by chi-square test (46.4 vs. 55.1%; p<0.001) and by Kaplan-Meier and log-rank test (p<0.001). In the multivariable random-effects Cox regression, plateau pressure < 30 cm H2O was significantly associated with lower mortality (HR=0.84, 95% CI: 0.72-0.99, p=0.038). ALI in sepsis was associated with higher mortality, especially when an inspiratory pressure-limited mechanical ventilation approach was not implemented.
Authors:
Ignacio Martin-Loeches; Candelaria de Haro; R Phillip Dellinger; Ricard Ferrer; Gary S Phillips; Mitchell M Levy; Antonio Artigas
Related Documents :
2575786 - Cardiac effects of secretin; an approach to its mechanisms of action as shown by beta-a...
2887186 - Responses to mental stress and physical provocations before and during long term treatm...
66056 - Pharmacodynamic actions of midodrine, a new alpha-adrenergic stimulating agent, and its...
7160416 - Comparative evaluation of the new vasodilator carprazidil and minoxidil in the treatmen...
16128376 - Combined doppler index to track instantaneous changes in left ventricular filling press...
7669116 - Contact pressure prediction in total knee joint replacements. part 1: general elasticit...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  PM10, and children's respiratory symptoms and lung function in the PATY study.
Next Document:  Pulmonary hypertension associated with benfluorex exposure.