Document Detail

Effectiveness and infant acceptance of the Rx medibottle versus the oral syringe.
MedLine Citation:
PMID:  11310514     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To compare the effectiveness and infant acceptance of drug delivery of the Rx medibottle with the standard oral syringe. DESIGN: Prospective open-label, randomized, crossover clinical study. SETTING: General pediatric outpatient clinic at an urban university. SUBJECTS: Thirty healthy, bottle-fed infants, aged 2-14 months, receiving routine vaccinations. INTERVENTION: Each infant received a single dose of acetaminophen (Tempra syrup), with one-half delivered by the Rx medibottle and one-half delivered with an oral syringe. MEASUREMENTS AND MAIN RESULTS: Three raters independently evaluated effectiveness and infant acceptance of each drug-delivery device. Effectiveness was based on the percentage of infants receiving 100% of the intended dose. Infant acceptance was scored using a validated infant medication acceptance scale (MAS, 10 = highest level). Significantly more infants received 100% of the intended dose with the Rx medibottle (93.3%) than with the oral syringe (56.7%, p=0.0074). Infants had a significantly higher mean MAS score when using the Rx medibottle (8.3+/-1.8 vs 7.3+/-1.7, p=0.002). In addition, a significantly higher percentage had ideal MAS scores of 9 or above with the Rx medibottle (73%) compared with the oral syringe (17%, p=0.0001). CONCLUSION: The Rx medibottle was more effective and had a higher level of infant acceptance than the oral syringe. Although further studies are necessary, this suggests that the Rx medibottle may be a better method of delivering liquid drug and may increase infant adherence.
D M Kraus; L A Stohlmeyer; P R Hannon; S A Freels
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacotherapy     Volume:  21     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-19     Completed Date:  2001-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-23     Citation Subset:  IM    
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
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MeSH Terms
Acetaminophen / administration & dosage*
Administration, Oral
Analgesics, Non-Narcotic / administration & dosage*
Bottle Feeding*
Cross-Over Studies
Equipment Design
Infant Equipment*
Patient Satisfaction*
Prospective Studies
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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