Document Detail


Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS.
MedLine Citation:
PMID:  20428637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment na?ve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL <80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment na?ve and 76 (53%) previously exposed. Odds ratio (OR) in na?ve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment na?ve patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen.
Authors:
Fl?via Marinho Sant'Anna; Luciane Velasque; Marli Jane Costa; Carolina Arana Schmaltz; Mariza Gon?alves Morgado; Maria Cristina Louren?o; Beatriz Grinsztejn; Val?ria Cavalcanti Rolla
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  13     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Affiliation:
Instituto de Pesquisa Cl?nica Evandro Chagas, Funda??o Oswaldo Cruz, Rio de Janeiro, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / administration & dosage*
Antiretroviral Therapy, Highly Active*
Antitubercular Agents / administration & dosage*
CD4 Lymphocyte Count
Female
Follow-Up Studies
HIV Infections / complications,  drug therapy*
Humans
Male
Middle Aged
Rifampin / administration & dosage*
Treatment Outcome
Tuberculosis / complications,  drug therapy*
Viral Load
Young Adult
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Antitubercular Agents; 13292-46-1/Rifampin

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