Document Detail

Effectiveness of heparin solution versus normal saline in maintaining patency of intravenous locks in neonates: a double blind randomized controlled study.
MedLine Citation:
PMID:  21722168     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to evaluate the effect of heparin versus saline as flush solution for maintaining patency in peripheral intravenous locks in neonates and to investigate whether other variables influence the longevity of intravenous locks.
BACKGROUND: Heparin is usually used as a regular flush solution to prevent occlusion of peripheral intravenous locks in neonates. There is no clear recommendation using heparin or saline flushing peripheral intravenous locks in neonates. The disadvantage of heparin cannot be ignored, especially in this patient group.
METHODS: In a double blind prospective randomized study, neonates (gestational age >27 weeks) with intravenous locks were randomly assigned to receive heparin or saline as a flush solution in a 21-month period (2002-2004). The main outcome was the duration of patency.
RESULTS: Eighty-eight neonates were included. No statistically significant difference was found in patency of peripheral intravenous locks flushed with 0.7 mL heparin (10 units/mL) (N = 42, median 56 hours) or 0.7 mL saline (N = 46, median 61 hours). When the analysis was confined to removed locks because of non-elective events, no statistically significant difference was found in duration of patency (P = 0.27).
CONCLUSION: As no difference in patency could be established, using saline as a flush solution is preferable to heparin in peripheral intravenous locks in neonates, given the greater likelihood of complications associated with heparin. Although these data are more than 5 years old, the relevance of the outcome is still important for the clinical practice because of the potential adverse effects of heparin in these vulnerable infants.
Inge J J Arnts; Johanna A Heijnen; Henriette T M Wilbers; Gert-Jan van der Wilt; Johannes M M Groenewoud; Kian D Liem
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2011-07-03
Journal Detail:
Title:  Journal of advanced nursing     Volume:  67     ISSN:  1365-2648     ISO Abbreviation:  J Adv Nurs     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-21     Completed Date:  2012-03-07     Revised Date:  2012-09-05    
Medline Journal Info:
Nlm Unique ID:  7609811     Medline TA:  J Adv Nurs     Country:  England    
Other Details:
Languages:  eng     Pagination:  2677-85     Citation Subset:  IM; N    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Department of Neonatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Anticoagulants / administration & dosage,  therapeutic use*
Catheterization, Peripheral / instrumentation,  methods*,  nursing
Catheters, Indwelling*
Clinical Nursing Research
Double-Blind Method
Heparin / administration & dosage,  therapeutic use*
Infant, Newborn
Infusions, Intravenous / methods
Kaplan-Meier Estimate
Prospective Studies
Sodium Chloride / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 7647-14-5/Sodium Chloride; 9005-49-6/Heparin
Comment In:
Evid Based Nurs. 2012 Jul;15(3):86-7   [PMID:  22447654 ]

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